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Review
. 2021 Jul 1;32(4):362-368.
doi: 10.1097/ICU.0000000000000766.

The management of neurotrophic keratitis

Samir Jabbour  1 , Christopher Ashton  1 , Shafi Balal  1 , Abigail Kaye  1 , Sajjad Ahmad  1   2
Affiliations
Review

The management of neurotrophic keratitis

Samir Jabbour et al. Curr Opin Ophthalmol. .

Abstract

Purpose of review: The management of neurotrophic keratitis (NK) has evolved in the last decade. The present article reviews updated management guidelines of this entity, as well as future innovations in the field.

Recent findings: The advent of confocal microscopy has allowed for the first time to image corneal nerves. In addition, multiple novel topical treatments such as nerve growth factor have improved the prognosis of this disease, with many other in the pipeline. Finally, corneal nerve restoration is now possible with corneal neurotization procedures.

Summary: Many novel treatments based on agents that stimulate nerve regrowth are now available to treat NK. Improvement in neurotization procedures could also address advanced stages of this disease with surgery.

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References

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    1. Labetoulle M, Baudouin C, Calonge M, et al. Role of corneal nerves in ocular surface homeostasis and disease. Acta Ophthalmol 2019; 97:137–145.
    1. Bonini S, Rama P, Olzi D, Lambiase A. Neurotrophic keratitis. Eye 2003; 17:989–995.

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