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Comment
. 2021 May 8;6(1):179.
doi: 10.1038/s41392-021-00620-5.

EpiMap: Fine-tuning integrative epigenomics maps to understand complex human regulatory genomic circuitry

Affiliations
Comment

EpiMap: Fine-tuning integrative epigenomics maps to understand complex human regulatory genomic circuitry

Dave S B Hoon et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Histone marks on RNF123 gene obtained from EpiMap. EpiMap is a compendium of epigenomes across multiple annotation projects: Genomics of gene regulation, ENCODE, ROADMAP, GWAS, and Chrom Impute. Presented are the histone modifications at the promoter region of RNF123 gene (Chromosome 3, p21.31) in primary melanocytes (melanocytes), metastatic melanoma (COLO829, SK-MEL5, and RPMI7951) and glioblastoma cell lines (H54, M059J, and A172). All the tracks were downloaded from EpiMap and visualized on WASHU epigenome browser

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References

    1. Boix CA, et al. Regulatory genomic circuitry of human disease loci by integrative epigenomics. Nature. 2021;590:300–307. doi: 10.1038/s41586-020-03145-z. - DOI - PMC - PubMed
    1. Moore JE, et al. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 2020;583:699–710. doi: 10.1038/s41586-020-2493-4. - DOI - PMC - PubMed
    1. Buniello A, et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res. 2019;47:D1005–d1012. doi: 10.1093/nar/gky1120. - DOI - PMC - PubMed
    1. Kravtsova-Ivantsiv Y, et al. KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth. Cell. 2015;161:333–347. doi: 10.1016/j.cell.2015.03.001. - DOI - PubMed
    1. Iida Y, et al. Epigenetic regulation of KPC1 ubiquitin ligase affects the NF-κB pathway in melanoma. Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res. 2017;23:4831–4842. doi: 10.1158/1078-0432.CCR-17-0146. - DOI - PMC - PubMed

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