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. 2021 Oct 20;73(8):1524-1527.
doi: 10.1093/cid/ciab414.

Enhanced Clostridioides difficile Infection Prevention With a Pharmacy-Controlled Policy That Adds a 3-Strain Lactobacillus Probiotic Concomitantly to Antibiotic Therapy

Pierre-Jean Maziade  1 , Noam Ship  2 , Jason C Sniffen  3 , Ellie J C Goldstein  4
Affiliations

Enhanced Clostridioides difficile Infection Prevention With a Pharmacy-Controlled Policy That Adds a 3-Strain Lactobacillus Probiotic Concomitantly to Antibiotic Therapy

Pierre-Jean Maziade et al. Clin Infect Dis. .

Abstract

When 70% of antibiotic users took a 3-strain Lactobacillus probiotic preparation the hospital-wide rate of healthcare-associated Clostridioides difficile infection improved significantly. The incidence of C. difficile infection for those taking the probiotic along with multiple antibiotics or a single high-risk antibiotic was decreased by at least half.

Keywords: Clostridium difficile infection; Lactobacillus; CL1285; Primary prevention; Probiotic.

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Figures

Figure 1.
Figure 1.
Hospital-wide rate of primary healthcare-associated Clostridioides difficile (HA-CDI) cases (A) and recurrent CDI episodes (B) per 10 000 patient-days (pt-days) for each semiannual period. The semiannual periods refer to hospital data from the spring through summer [Periods 1-7] or from the autumn through winter [Periods 8-13]. Error bars for simple proportion represent 95% confidence intervals calculated with Fisher exact test. *P < .01 for hospital-wide rate of primary HA-CDI cases versus 1 year earlier; †P < .01 for hospital-wide rate of primary HA-CDI cases versus 1 and 2 years earlier; ‡P < .01 for hospital-wide rate of first recurrent HA-CDI cases versus 1 and 2 years earlier.
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