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. 1988 Jan-Mar;13(1):19-22.
doi: 10.1007/BF03189923.

Distribution of SC-4453, a new semi-synthetic derivative of digoxin, following an infusion preceded by an i.v. loading dose in the guinea-pig. Binding to plasma proteins

F Randimbivololona  1
Affiliations

Distribution of SC-4453, a new semi-synthetic derivative of digoxin, following an infusion preceded by an i.v. loading dose in the guinea-pig. Binding to plasma proteins

F Randimbivololona. Eur J Drug Metab Pharmacokinet. 1988 Jan-Mar.

Abstract

The tissue distribution of 12 alpha-[3H]SC-4453 was studied in the guinea-pig after a 15 hours infusion at the rate of 4 micrograms/h/kg, preceded by an IV loading dose. At the end of the infusion, at the steady state, the skeletal muscle apparently presented the highest concentration of SC-4453 (24 ng/g) and the brain the lowest (1.2 ng/g), which demonstrates the presence of a blood-brain barrier to this compound. Our results also show that this new semi-synthetic cardiotonic presents a weak affinity to plasma proteins (25%).

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