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. 1988 Jul 15;44(7):611-3.
doi: 10.1007/BF01953314.

Enhanced toxicity of the immunosuppressant ovalicin upon application to the skin

H Stähelin  1
Affiliations

Enhanced toxicity of the immunosuppressant ovalicin upon application to the skin

H Stähelin. Experientia. .

Abstract

The non-myelotoxic immunosuppressive sesquiterpene ovalicin, of fungal origin, is much more toxic when applied to the skin of animals than when injected i.v., the LD-50 in guinea pigs being 0.2 in the first case and 7 mg/kg in the second. It elicits aphagia and adipsia. It is assumed that ovalicin effects are due to slow, tissue-specific, metabolic toxification.

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