Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 May;37(3):351-353.
doi: 10.1007/s12055-020-01103-y. Epub 2021 Jan 8.

Virtual crossmatch-prodigal saviour of cardiac transplants in India

Talha Meeran  1 , Anvay Mulay  2 , Ashish Gaur  2 , Sandeep Sinha  2 , Rajeshwari Basavanna  3
Affiliations
Case Reports

Virtual crossmatch-prodigal saviour of cardiac transplants in India

Talha Meeran et al. Indian J Thorac Cardiovasc Surg. 2021 May.

Abstract

Positive anti-human leukocyte antigen (HLA) antibodies are considered a contraindication for cardiac transplantation in India, due to its negative impact on cardiac allograft survival and increased chances of rejection post-transplant. Single antigen bead (SAB) assay helps to further characterize these antibodies. Our case portrays India's first reported successful cardiac transplant utilizing a virtual crossmatch (VXM)-based approach in a patient with positive anti-HLA antibody screen and SAB assay. We propose that adopting such an approach, in select cases, in India is certainly feasible. This approach would lead to increasing the potential donor pool and mitigate the chances of post-transplant rejection. With increased demands, the SAB assay cost would reduce, further improving its cost-effectiveness.

Keywords: Cardiac transplant; Rejection; SAB; Virtual crossmatch.

PubMed Disclaimer

Conflict of interest statement

Conflict of interestThe authors declare that they have no conflicts of interest.

References

    1. Nwakanma LU, Williams JA, Weiss ES, Russell SD, Baumgartner WA, Conte JV. Influence of pretransplant panel-reactive antibody on outcomes in 8,160 heart transplant recipients in recent era. Ann Thorac Surg. 2007;84:1556–1562. doi: 10.1016/j.athoracsur.2007.05.095. - DOI - PubMed
    1. Patel R, Terasaki PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med. 1969;280:735–739. doi: 10.1056/NEJM196904032801401. - DOI - PubMed
    1. Kobashigawa J, Colvin M, Potena L, Dragun D, Crespo-Leiro MG, Delgado JF, Olymbios M, Parameshwar J, Patel J, Reed E, Reinsmoen N, Rodriguez ER, Ross H, Starling RC, Tyan D, Urschel S, Zuckermann A. The management of antibodies in heart transplantation: an ISHLT consensus document. J Heart Lung Transplant. 2018;37:537–547. doi: 10.1016/j.healun.2018.01.1291. - DOI - PubMed
    1. Costanzo MR, Dipchand A, Starling R, et al. The International Society of Heart and Lung Transplantation guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29:914–956. doi: 10.1016/j.healun.2010.05.034. - DOI - PubMed
    1. Clerkin KJ, See SB, Farr MA, Restaino SW, Serban G, Latif F, Li L, Colombo PC, Vlad G, Ray B, Vasilescu ER, Zorn E. Comparative assessment of anti-HLA antibodies using two commercially available Luminex-based assays. Transplantation Direct. 2017;3:e218. doi: 10.1097/TXD.0000000000000734. - DOI - PMC - PubMed

Publication types

LinkOut - more resources