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. 1988 May;25(2):277-87.

Inherited frailty and longevity

J W Vaupel  1
Affiliations
  • PMID: 3396752

Inherited frailty and longevity

J W Vaupel. Demography. 1988 May.

Abstract

The life spans of parents and children appear only weakly related, even though parents affect their children's longevity through both genetic and environmental influences. These influences can be summarized as a correlation between parents' and children's frailty. It is shown that even if children perfectly inherit their frailty from their parents, parents' life spans explain little of the variance in children's life spans, because the variance in life expectancies among people with different frailties is small compared with the variance in life spans among people at the same level of frailty. By interpreting frailty as a relative risk in a proportional-hazard model, longevity as a duration or waiting time, and inheritance as an invariance in relative risk over time, one can extend this result to repeatable events involving fertility, migration, marriage, unemployment, and so forth.

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References

    1. Soc Biol. 1980 Fall;27(3):211-9 - PubMed
    1. Am J Med Genet. 1978;2(2):105-20 - PubMed
    1. Milbank Mem Fund Q Health Soc. 1982 Spring;60(2):183-244 - PubMed
    1. Gerontologist. 1984 Aug;24(4):354-9 - PubMed
    1. Milbank Mem Fund Q Health Soc. 1983 Summer;61(3):397-419 - PubMed