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Review
. 2021 Apr 28;27(16):1728-1737.
doi: 10.3748/wjg.v27.i16.1728.

Hepatitis C virus micro-elimination: Where do we stand?

Alessandra Mangia  1 , Rosa Cotugno  2 , Giovanna Cocomazzi  2 , Maria Maddalena Squillante  2 , Valeria Piazzolla  2
Affiliations
Review

Hepatitis C virus micro-elimination: Where do we stand?

Alessandra Mangia et al. World J Gastroenterol. .

Abstract

Hepatitis C virus (HCV) elimination by 2030, using direct-acting antiviral treatments, has been promoted by the World Health Organization. This achievement is not attainable, however, particularly after the 2020 pandemic of the coronavirus disease 2019. Consequently, the more realistic objective of eliminating HCV from population segments for which targeted strategies of prevention and treatment are easily attained has been promoted in Europe, as a valid alternative. The underlying idea is that micro-elimination will ultimately lead to macro-elimination. The micro-elimination strategy may target different specific populations and at-risk groups. Different settings, including prisons and hospitals, have also been identified as micro-elimination scenarios. In addition, dedicated micro-elimination strategies have been designed that are tailored at the geographical level according to HCV epidemiology and individual country's income. The main elements of a valid and successful micro-elimination project are reliable epidemiological data and active involvement of all the stakeholders. Community involvement represents another essential component for a successful program.

Keywords: Hepatitis C virus RNA; Hepatitis C virus antibodies; Hepatitis C virus diagnosis; Hepatitis C virus elimination; Hepatitis C virus epidemiology; Hepatitis C virus infection.

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Conflict of interest statement

Conflict-of-interest statement: Mangia A has served in an advisory role and received research grants from Gilead Sciences, MSD, Intercept, and Spring Bank; all other authors declare having no conflicts of interest.

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