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Review
. 2021 Apr 7;18(11):2347-2354.
doi: 10.7150/ijms.57990. eCollection 2021.

The associations and roles of microRNA single-nucleotide polymorphisms in cervical cancer

Yaheng Li  1 , Chuanyin Li  1 , Shuyuan Liu  1 , Jia Yang  1 , Li Shi  1 , Yufeng Yao  1
Affiliations
Review

The associations and roles of microRNA single-nucleotide polymorphisms in cervical cancer

Yaheng Li et al. Int J Med Sci. .

Abstract

Cervical cancer is one of the fourth most common gynecological malignancies and has been identified as the fourth leading cause of cancer death in women worldwide. MicroRNAs (miRNAs) are single-stranded sequences of noncoding RNAs that are approximately 22-24 nucleotides in length. They modulate posttranscriptional mRNA expression and play critical roles in cervical cancer. Single nucleotide polymorphisms (SNPs) in miRNA genes may alter miRNA expression and maturation and have been associated with various cancers. This review mainly focuses on the roles of SNPs in miRNA genes in the development of cervical cancer and summarizes the research progress of miRNA SNPs in cervical cancer and their molecular regulation mechanisms.

Keywords: cervical cancer; miRNAs; regulation; single nucleotide polymorphisms.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

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