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Review
. 2021 Apr 22:12:630385.
doi: 10.3389/fphar.2021.630385. eCollection 2021.

Isoliensinine: A Natural Compound with "Drug-Like" Potential

Yan Cheng  1   2 , Hong-Li Li  1 , Zi-Wei Zhou  1   2 , Hui-Zhi Long  1   2 , Hong-Yu Luo  1   2 , Dan-Dan Wen  1 , Lin Cheng  3 , Li-Chen Gao  1   2
Affiliations
Review

Isoliensinine: A Natural Compound with "Drug-Like" Potential

Yan Cheng et al. Front Pharmacol. .

Abstract

Isoliensinine, a bisbenzylisoquinoline alkaloid isolated from Nelumbo nucifera Gaertn, exerts a variety of beneficial effects, such as antitumor, cardioprotective, antioxidant, antidepressant, and anti-HIV effects, and ameliorates T2DM with hyperlipidemia and Alzheimer's disease. In this article, the recent literature on isoliensinine, including its pharmacology, pharmacokinetics, and synthesis and extraction, is summarized. Moreover, possible future prospects and research directions are also discussed. Studies on isoliensinine were found by searching a combination of keywords including "pharmacology," "pharmacokinetics," and "synthesis and extraction" in the main databases, including PubMed, Google Scholar, Web of Science, NCBI, and Wan Fang. Many studies have pointed out that a major limitation of isoliensinine is its poor solubility in aqueous media. Considering its advantages and limitations, isoliensinine can be used as a lead compound to develop novel efficient and low-toxicity derivatives. The available literature indicates that isoliensinine displays "drug-like" potential. Additionally, there are many related issues and novel mechanisms that need to be explored.

Keywords: isoliensinine; mechanism; pharmacokinetics; pharmacology; synthesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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