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. 2021 Apr 21:2021:5524566.
doi: 10.1155/2021/5524566. eCollection 2021.

Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo

Thai Van Thanh Le  1 , Huy Ngoc Phan  2 , Tran Ngoc Dang  3 , Le Duy Pham  4
Affiliations

Increased Circulatory Interleukin-17A Levels in Patients with Progressive and Leukotrichial Vitiligo

Thai Van Thanh Le et al. Dermatol Res Pract. .

Abstract

Background: Vitiligo is a chronic condition characterized by skin depigmentation. Although not life-threatening, it significantly impacts quality of life. The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Mounting evidence supports the importance of autoreactive T cells and, particularly interleukin-17A- (IL-17A-) secreting Th17 cells, in vitiligo. IL-17A targeting has been proven successful in various inflammatory dermatological conditions, including psoriasis and lupus erythematosus.

Objective: We evaluated the relationship between serum levels of IL-17A and the clinicopathological characteristics of Vietnamese vitiligo patients.

Methods: In this cross-sectional study, we analyzed data from 52 nonsegmental vitiligo patients and 50 age- and sex-matched healthy individuals. Serum levels of IL-17A were measured using an enzyme-linked immunosorbent assay. We evaluated the correlation between IL-17A levels and clinical characteristics including leukotrichia, disease duration, vitiligo activity, and body surface area involvement.

Results: Patients with progressive vitiligo had significantly higher IL-17A levels than patients with stable vitiligo (P = 0.014) or healthy individuals (P = 0.002). In addition, serum IL-17A levels were higher in vitiligo patients with leukotrichia than in patients without it (P = 0.04). Furthermore, serum IL-17A levels were negatively correlated with age (r = -0.39, P = 0.004) and age of onset (r = -0.33, P = 0.016) in vitiligo patients.

Conclusions: Higher serum levels of IL-17A in patients with progressive vitiligo and leukotrichia suggest a potential role of IL-17A in melanocyte destruction in the epidermis and the follicular matrix.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Serum levels of IL-17A in active and stable disease and healthy controls.
Figure 2
Figure 2
The correlations of serum IL-17A levels with age (a) and age of onset (b) in vitiligo patients.
See this image and copyright information in PMC

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