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Review
. 2021 May 1;17(4):255-260.
doi: 10.1002/cld.1047. eCollection 2021 Apr.

Pathology of Cholangiocarcinoma and Combined Hepatocellular-Cholangiocarcinoma

Murli Krishna  1
Affiliations
Review

Pathology of Cholangiocarcinoma and Combined Hepatocellular-Cholangiocarcinoma

Murli Krishna. Clin Liver Dis (Hoboken). .
No abstract available

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Figures

FIG 1
FIG 1
iCC, corresponding to the small‐duct type. Tumor forms a well‐defined peripheral subcapsular mass. Note the nodularity of the background liver, indicating fibrosis secondary to chronic liver disease.
FIG 2
FIG 2
iCC, large‐duct type. Tumor has a mixed periductal (arrows) and mass‐forming (arrowhead) pattern.
FIG 3
FIG 3
pCC. Tumor has an intraductal (small arrow) and mixed intraductal‐periductal (large arrow) infiltrating pattern.
FIG 4
FIG 4
(A) Tubular (acinar) pattern of CC with typical desmoplastic stromal response. (B) CC with mixed acinar (right) and sarcomatoid (left) patterns. (C) Characteristic cholangiolar pattern for a small‐duct CC, with focal pleomorphic cytological features (arrows). (D) CC with a cholangiolar pattern in a core biopsy. A metastasis would need to be excluded, such as from a breast primary. (E) CC arising from a large intrahepatic duct, with invasive tumor (CC) and HG BilIN. (F) IPN characterized by a papillary proliferation in a dilated duct. DW is seen at the periphery.
FIG 5
FIG 5
Hilar CC arising in the setting of PSC. Tumor is well differentiated with infiltrating glands containing mucinous epithelium. A cluster of benign periductal glands is present (arrow), and the duct lumen (D) is markedly narrowed.
FIG 6
FIG 6
HCC‐CC, with HCC and CC components.
See this image and copyright information in PMC

References

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