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. 1988 Jun;119(2):355-63.
doi: 10.1093/genetics/119.2.355.

Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans

L A Jacobson  1 , L Jen-Jacobson, J M Hawdon, G P Owens, M A Bolanowski, S W Emmons, M V Shah, R A Pollock, D S Conklin
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Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans

L A Jacobson et al. Genetics. 1988 Jun.

Abstract

Mutants of Caenorhabditis elegans having about 10% of wild-type activity of the aspartyl protease cathepsin D have been isolated by screening. Mutant homozygotes have normal growth rates and no obvious morphological or developmental abnormalities. The mutant gene (cad-1) has been mapped to the right extremity of linkage group II. Heterozygous animals (cad-1/+) show intermediate enzyme levels and animals heterozygous for chromosomal deficiencies of the right extremity of linkage group II have 50% of wild-type activity. Cathepsin D purified from a mutant strain has a lower activity per unit mass of pure enzyme. These data suggest that cad-1 is a structural gene for cathepsin D.

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References

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