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. 2021 Jan;9(4):373-378.
doi: 10.52547/rbmb.9.4.373.

LAMP3 (CD208) Expression in Squamous Cell Carcinoma and Epithelial Dysplasia of the Oral Cavity and Clinicopathological Characteristics of Unfavorable Prognosis

Mehdi Shahabinejad  1 , Reza Zare  2 , Zeynab Asadi  3 , Farnaz Mohajertehran  1
Affiliations

LAMP3 (CD208) Expression in Squamous Cell Carcinoma and Epithelial Dysplasia of the Oral Cavity and Clinicopathological Characteristics of Unfavorable Prognosis

Mehdi Shahabinejad et al. Rep Biochem Mol Biol. 2021 Jan.

Abstract

Background: This study aimed to evaluate LAMP3 (CD208) gene expression in oral squamous cell carcinoma (OSCC) and dysplastic oral epithelium by quantitative real-time polymerase chain reaction (qPCR) and compare LAMP3 expression in different disease grades and stages.

Methods: In this study, 60 OSCC and dysplastic oral epithelium samples were obtained from the Mashhad University of Medical Sciences together with their demographic and clinicopathological documents. LAMP3 expression was measured by qPCR.

Results: LAMP3 expression was significantly greater in OSCC than in dysplasia samples (P=0.001), in grade III OSCC than in grades I and II, and also greater in advanced than in early OSCC disease stage (P=0.001).

Conclusion: The significantly greater LAMP3 expression in OSCC than in dysplastic epithelium indicates a role for LAMP3 in carcinogenesis in oral mucosa. Our results suggest LAMP3 may be useful as an anticancer target and/or to predict disease pathogenesis in OSCC patient's cells.

Keywords: Clinicopathological; Grade, Epithelial dysplasia; LAMP3; Stage, Squamous cell carcinoma..

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Figures

Fig. 1
Fig. 1
Amplification plot for LAMP3 and GAPDH expression.
Fig. 2
Fig. 2
Melt curve for LAMP3 and GAPDH expression.
See this image and copyright information in PMC

References

    1. Neville BW, Damm D, Allen C, Bouquot J. Salivary Gland Pathology. Oral and Maxillofacial Pathology. Elsevier, St. Louis. 2009
    1. Regezi JA, Sciubba J, Jordan RC. Oral pathology: clinical pathologic correlations. Elsevier Health Sciences. 2016
    1. Pektaș ZÖ, Keskin A, Günhan Ö, Karslioğlu Y. Evaluation of nuclear morphometry and DNA ploidy status for detection of malignant and premalignant oral lesions: quantitative cytologic assessment and review of methods for cytomorphometric measurements. . Journal of oral and maxillofacial surgery. 2006;64(4):628, 35. - PubMed
    1. Marshall JR, Graham S, Haughey BP, Shedd D, O'Shea R, Brasure J, et al. Smoking, alcohol, dentition and diet in the epidemiology of oral cancer. European Journal of Cancer Part B . Oral Oncology. 1992;28(1):9–15. - PubMed
    1. Hindle I, Downer M, Speight P. The epidemiology of oral cancer. British Journal of Oral and Maxillofacial Surgery. . 1996;34(5):471–6. - PubMed

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