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. 2021 Jun;32(6):1712-1723.
doi: 10.1111/jce.15080. Epub 2021 May 16.

Rate and impact on patient outcome and healthcare utilization of complications requiring surgical revision: Subcutaneous versus transvenous implantable defibrillator therapy

Pietro Palmisano  1 , Matteo Ziacchi  2 , Ernesto Ammendola  3 , Antonio D'Onofrio  4 , Gabriele Dell'Era  5 , Mattia Laffi  6 , Mauro Biffi  2 , Gerardo Nigro  3 , Walter Bianchi  4 , Eleonora Prenna  5 , Andrea Angeletti  2 , Alessandro Guido  1 , Giulia Stronati  7 , Germano Gaggioli  6 , Antonio Dello Russo  7 , Michele Accogli  1 , Federico Guerra  7 ; Italian Association of Arrhythmology and Cardiac Pacing (AIAC)
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Rate and impact on patient outcome and healthcare utilization of complications requiring surgical revision: Subcutaneous versus transvenous implantable defibrillator therapy

Pietro Palmisano et al. J Cardiovasc Electrophysiol. 2021 Jun.

Abstract

Introduction: Comparison data on management of device-related complications and their impact on patient outcome and healthcare utilization between subcutaneous implantable cardioverter-defibrillator (S-ICD) and transvenous ICD (TV-ICD) are lacking. We designed this prospective, multicentre, observational registry to compare the rate, nature, and impact of long-term device-related complications requiring surgical revision on patient outcome and healthcare utilization between patients undergoing S-ICD or TV-ICD implantation.

Methods and results: A total of 1099 consecutive patients who underwent S-ICD or TV-ICD implantation were enrolled. Propensity matching for baseline characteristics yielded 169 matched pairs. Rate, nature, management, and impact on patient outcome of device-related complications were analyzed and compared between two groups. During a mean follow-up of 30 months, device-related complications requiring surgical revision were observed in 20 patients: 3 in S-ICD group (1.8%) and 17 in TV-ICD group (10.1%; p = .002). Compared with TV-ICD patients, S-ICD patients showed a significantly lower risk of lead-related complications (0% vs. 5.9%; p = .002) and a similar risk of pocket-related complications (0.6 vs. 2.4; p = .215) and device infection (0.6% vs. 1.2%; p = 1.000). Complications observed in S-ICD patients resulted in a significantly lower number of complications-related rehospitalizations (median 0 vs. 1; p = .013) and additional hospital treatment days (1.0 ± 1.0 vs. 6.5 ± 4.4 days; p = .048) compared with TV-ICD patients.

Conclusions: Compared with TV-ICD, S-ICD is associated with a lower risk of complications, mainly due to a lower risk of lead-related complications. The management of S-ICD complications requires fewer and shorter rehospitalizations.

Keywords: complications; implantable cardioverter-defibrillator; outcomes; subcutaneous ICD; transvenous ICD.

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References

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