Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May;49(5):3000605211008326.
doi: 10.1177/03000605211008326.

Analysis of risk factors for different subtypes of acute coronary syndrome

Lei Zhang  1 , Juledezi Hailati  1 , Xiaoyun Ma  1 , Jiangping Liu  1 , Zhiqiang Liu  1 , Yuchun Yang  1 , Pengyi He  1 , Muhuyati Wulasihan  1
Affiliations

Analysis of risk factors for different subtypes of acute coronary syndrome

Lei Zhang et al. J Int Med Res. 2021 May.

Abstract

Aims: To investigate the different risk factors among different subtypes of patients with acute coronary syndrome (ACS).

Methods: A total of 296 patients who had ACS were retrospectively enrolled. Blood and echocardiographic indices were assessed within 24 hours after admission. Differences in risk factors and Gensini scores of coronary lesions among three groups were analyzed.

Results: Univariate analysis of risk factors for ACS subtypes showed that age, and levels of fasting plasma glucose, amino-terminal pro-brain natriuretic peptide, and creatine kinase isoenzyme were significantly higher in patients with non-ST-segment elevation myocardial infarction (NSTEMI) than in those with unstable angina pectoris (UAP). Logistic multivariate regression analysis showed that amino-terminal pro-brain natriuretic peptide and the left ventricular ejection fraction (LVEF) were related to ACS subtypes. The left ventricular end-diastolic diameter was an independent risk factor for UAP and ST-segment elevation myocardial infarction (STEMI) subtypes. The severity of coronary stenosis was significantly higher in NSTEMI and STEMI than in UAP. Gensini scores in the STEMI group were positively correlated with D-dimer levels (r = 0.429) and negatively correlated with the LVEF (r = -0.602).

Conclusion: Different subtypes of ACS have different risk factors. Our findings may have important guiding significance for ACS subtype risk assessment and clinical treatment.

Keywords: Acute coronary syndrome; Gensini score; coronary stenosis; non-ST-segment elevation myocardial infarction; risk factor; unstable angina pectoris.

PubMed Disclaimer

References

    1. Fanaroff AC, Rymer JA, Goldstein SA. Acute Coronary Syndrome. JAMA 2015; 314: 1990. doi: 10.1001/jama.2015.12743. - PubMed
    1. Cornara S, Crimi G, Somaschini A, et al. Systemic inflammatory status is associated with increased platelet reactivity in the early period after acute coronary syndromes. Platelets 2018; 29: 528–530. doi: 10.1080/09537104.2018.1457782. - PubMed
    1. Lin Y, Chen H, Wang Y, et al. Association of serum ADAMTS7 levels and genetic variant rs1994016 with acute coronary syndrome in a Chinese population: A case control study. Atherosclerosis 2018; 275: 312–318. doi: 10.1016/j.atherosclerosis.2018.06.872. - PubMed
    1. Fox KA, Carruthers KF, Dunbar DR, et al. Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK-Belgian Study). Eur Heart J 2010; 31: 2755–2764. doi: 10.1093/eurheartj/ehq326. - PubMed
    1. Alberty R, Studencan M, Kovar F. Prevalence of Conventional Cardiovascular Risk Factors in Patients with Acute Coronary Syndromes in Slovakia. Cent Eur J Public Health 2017; 25: 77–84. doi: 10.21101/cejph.a4351. - PubMed

LinkOut - more resources