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. 2021 Sep;77(9):3921-3932.
doi: 10.1111/jan.14879. Epub 2021 May 10.

Interventions to improve physical activity in colorectal cancer survivors: protocol for a systematic review and meta-analysis of randomized controlled trials

Yves Paul Vincent Mbous  1 , Rowida Mohamed  1 , George A Kelley  2 , Kimberly Michelle Kelly  1
Affiliations

Interventions to improve physical activity in colorectal cancer survivors: protocol for a systematic review and meta-analysis of randomized controlled trials

Yves Paul Vincent Mbous et al. J Adv Nurs. 2021 Sep.

Abstract

Aim: To examine the effectiveness of physical activity (PA) interventions on changes in PA among colorectal cancer survivors, including an examination of theoretical versus atheoretical-driven approaches, with a special focus on their effectiveness across ethnic and racial minorities.

Design: Systematic review with aggregated data meta-analyses.

Data sources: Using six databases (Cochrane Central Register of Controlled Trials, PubMed, PsycINFO, CINAHL with full text, Scopus and Web of Science), we will screen for randomized controlled trials written in English from May 1, 1993 up to December 31, 2020.

Review methods: Dual study-selection and data abstraction will be performed. The Behavior Change Technique Taxonomy (v1) will be used to examine behavior change techniques among selected studies, while the Theory Coding Scheme will be used to assess the extent of theory use. Risk of bias will be assessed using the revised Cochrane risk-of-bias tool for randomized trials, while the strength of the evidence will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation instrument. In addition, intervention delivery will be appraised using the Template for Intervention Description and Replication. Changes in PA from each study will be calculated using the standardized mean difference effect size (Hedge's g). Results will be pooled using the inverse-variance heterogeneity model. Heterogeneity (Cochran's Q) and inconsistency (I2 ) will be examined, while small-study effects (publication bias) will be evaluated using the Doi plot and LFK Index. Meta-regression will also be conducted to examine for potential associations between changes in physical activity and selected covariates (theoretical versus atheoretical-driven approaches, race/ethnicity).

Discussion: This systematic review will identify specific racial/ethnic minorities for whom interventions are most effective and summarize the evidence of the effectiveness of theoretical vs. theoretical based intervention.

Impact: This systematic review can direct policymakers and practitioners towards actions that are likely to bring about positive physical activity behaviour change.

Keywords: Cancer Survivor; Colorectal cancer; Exercise; Meta-analysis; Minority Groups; Physical activity; Randomized controlled trial; Systematic review; theory.

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Conflict of interest statement

CONFLICTS OF INTEREST

Authors declare that they have no conflicts of interest.

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