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. 2021 May 3;4(5):e216481.
doi: 10.1001/jamanetworkopen.2021.6481.

Prevalence of High-Risk Nonvaccine Human Papillomavirus Types in Advanced Squamous Cell Carcinoma Among Individuals of African vs Non-African Ancestry

Erik A Williams  1   2 , Justin Newberg  2 , Kevin Jon Williams  3 , Meagan Montesion  2 , Brian M Alexander  2 , Douglas I Lin  2 , Julia A Elvin  2
Affiliations

Prevalence of High-Risk Nonvaccine Human Papillomavirus Types in Advanced Squamous Cell Carcinoma Among Individuals of African vs Non-African Ancestry

Erik A Williams et al. JAMA Netw Open. .

Abstract

This cross-sectional study assesses the prevalence of high-risk human papillomavirus (hrHPV) types not covered by the 9-valent HPV vaccine among patients of African vs non-African ancestry with advanced squamous cell carcinoma.

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Conflict of interest statement

Conflict of Interest Disclosures: Drs E. Williams, Newberg, Montesion, Alexander, Lin, and Elvin are employees or consultants of Foundation Medicine Inc, a wholly owned subsidiary of Roche Holdings Inc and Roche Finance Ltd, and these employees have equity interest in an affiliate of these Roche entities. No other disclosures were reported.

Figures

Figure.
Figure.. Comparative Frequencies of High-Risk Human Papillomavirus (hrHPV) Types Among hrHPV-Related Squamous Cell Carcinomas, Stratified by African vs Non-African Patient Ancestry
Displayed are data for hrHPV types affecting more than 10 patients of African ancestry in our multiethnic tumor archive. The Bonferroni correction for 5 multiple simultaneous comparisons was applied for each analysis; significant P values (<.05/5 = .01) are indicated within each panel. In panel A, a total of 3793 pan-hrHPV–related squamous cell carcinomas (321 [8%] from patients of African ancestry) were included for analysis. Stratified by primary site, panel B (cervix) included 1255 carcinomas (156 [12%] from patients of African ancestry); panel C (anus) included 865 carcinomas (71 [8%] from patients of African ancestry); panel D (head and neck) included 1363 carcinomas (49 [4%] from patients of African ancestry); panel E (vulva) included 147 carcinomas (19 [13%] from patients of African ancestry); panel F (vagina) included 91 carcinomas (15 [16%] from patients of African ancestry); and panel G (penis) included 72 carcinomas (11 [15%] from patients of African ancestry).
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