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. 2021 Jul;39(7):809-822.
doi: 10.1007/s40273-021-01031-8. Epub 2021 May 10.

What are the Economic Costs to Society Attributable to Alcohol Use? A Systematic Review and Modelling Study

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What are the Economic Costs to Society Attributable to Alcohol Use? A Systematic Review and Modelling Study

Jakob Manthey et al. Pharmacoeconomics. 2021 Jul.

Abstract

Background: Alcohol-attributable costs to society are captured by cost-of-illness studies, however estimates are often not comparable, e.g. due to the omission of relevant cost components. In this contribution we (1) summarize the societal costs attributable to alcohol use, and (2) estimate the total costs under the assumption that all cost components are considered.

Methods: A systematic review and meta-analyses were conducted for studies reporting costs from alcohol consumption for the years 2000 and later, using the EMBASE and MEDLINE databases. Cost estimates were converted into 2019 international dollars (Int$) per adult and into percentage of gross domestic product (GDP). For each study, weights were calculated to correct for the exclusion of cost indicators.

Results: Of 1708 studies identified, 29 were included, and the mean costs of alcohol use amounted to 817.6 Int$ per adult (95% confidence interval [CI] 601.8-1033.4), equivalent to 1.5% of the GDP (95% CI 1.2-1.7%). Adjusting for omission of cost components, the economic costs of alcohol consumption were estimated to amount to 1306 Int$ per adult (95% CI 873-1738), or 2.6% (95% CI 2.0-3.1%) of the GDP. About one-third of costs (38.8%) were incurred through direct costs, while the majority of costs were due to losses in productivity (61.2%).

Discussion: The identified cost studies were mainly conducted in high-income settings, with high heterogeneity in the employed methodology. Accounting for some methodological variations, our findings demonstrate that alcohol use continues to incur a high level of cost to many societies.

Registration: PROSPERO #CRD42020139594.

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Conflict of interest statement

All authors have completed the International Committee of Medical Journal Editors (ICMJE) uniform disclosure form at www.icmje.org/coi_disclosure.pdf, and declare no support from any organization for the submitted work. Sören Kuitunen-Paul reports grants and non-financial support from the German Federal Ministry of Health (BMG), personal fees from IAP-TUD GmbH, Gesundheitsamt Dresden as funded by the German Federal Centre for Health Education (BzgA), Mabuse Verlag, and personal fees from a consortium funding a public speech (AbbVie Germany, Almirall Hermal, Belano Medical, Celgene, Janssen-Cilag, LEO Pharma, Lilly Germany, Novartis Pharma, Pfizer Pharma, UCB Pharma), as well as non-financial support from the College on Problems of Drug Dependence (CPDD), outside the submitted work. The authors have no other relationships or activities that could appear to have influenced the submitted work.

Figures

Fig. 1
Fig. 1
Total costs presented in 2019 international dollars per adult (size of the data point represents study weight, with a larger size indicating inclusion of more relevant cost components). EU 28 all countries of the European Union and the UK)
Fig. 2
Fig. 2
Distribution of total costs per study for all studies that provided direct and indirect cost estimates (the vertical dashed line indicates the mean share of direct costs across all studies: 38.8%)
Fig. 3
Fig. 3
Distribution of direct costs for all studies that provided direct cost estimates
Fig. 4
Fig. 4
Distribution of indirect costs for all studies that provided indirect cost estimates (i.e. studies that incompletely reported the distribution of indirect costs were excluded from this plot)

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