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. 2021 Aug;52(4):542-544.
doi: 10.1111/age.13074. Epub 2021 May 10.

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy

K O'Donnell  1 , D Adin  1 , C E Atkins  1 , T DeFrancesco  1 , B W Keene  1 , S Tou  1 , K M Meurs  1
Affiliations

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy

K O'Donnell et al. Anim Genet. 2021 Aug.

Abstract

Hypertrophic cardiomyopathy (HCM) is the most common cause of heart disease in the domestic cat with a genetic predisposition in a few breeds. In the Maine Coon and Ragdoll breeds, two variants associated with the HCM phenotype have been identified in the cardiac myosin binding protein C gene (MYBPC3; p.Ala31Pro and p.Arg820Trp respectively), and a single variant has been identified in the myosin heavy chain gene (MYH7; p.Glu1883Lys) in one domestic cat with HCM. It is not known if these variants influence the development of HCM in other cohorts of the feline population. The objective of this study was to evaluate the presence of the known MYBPC3 and MYH7 variants in a population of cats with HCM. DNA was isolated from samples collected from non-Ragdoll and non-Maine Coon domestic cats diagnosed with HCM through the North Carolina State University College of Veterinary Medicine and genotyped for the three variants. One-hundred and three DNA samples from cats with HCM were evaluated from domestic shorthair, domestic longhair and purebred cats. All samples were wt for the MYBPC3 and MYH7 variants. Although this study was limited by its inclusion of cats from one tertiary hospital, the lack of these MYBPC3 and MYH7 variants in this feline HCM population indicates that the clinical utility of genetic testing for these variants may be isolated to the two cat breeds in which these variants have been identified. Further studies to identify the causative variants for the feline HCM population are warranted.

Keywords: HCM; cardiomyopathy; feline; genetic; mutation.

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References

    1. Fries R., Heaney A.M. & Meurs K.M. (2008) Prevalence of the myosin-binding protein C mutation in Maine Coon cats. Journal of Veterinary Internal Medicine 23, 893-6.
    1. Gil-Ortuno C., Sebastian-Marcos P., Sabater-Molina M., Nicolas-Rocamora E., Gimeno-Blanes J.R. & Fernandez del Palacio M.J. (2020) Genetics of feline hypertrophic cardiomyopathy. Clinical Genetics 98, 203-14.
    1. Granstrom S., Godiksen M.T.N., Christiansen M., Pipper C.B., Willesen J.L. & Koch J. (2011) Prevalence of hypertrophic cardiomyopathy in a cohort of British shorthair cats in Denmark. Journal of Veterinary Internal Medicine 25, 866-71.
    1. Haagstrom J., Luis F.V. & Wess G. (2015) Screening for hypertrophic cardiomyopathy in cats. Journal of Veterinary Cardiology 17, S134-9.
    1. Kraus M.S., Calvert C.A. & Jacobs G.J. (1999) Hypertrophic cardiomyopathy in a litter of five mixed-breed cats. Journal of the American Animal Hospital Association 35, 293-6.

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