Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Apr;2(3):263-6.
doi: 10.1016/0888-7543(88)90011-0.

Two different genes for X-linked retinitis pigmentosa

B Wirth  1 , M J Denton, J D Chen, M Neugebauer, F B Halliday, M van Schooneveld, J Donald, E M Bleeker-Wagemakers, P L Pearson, A Gal
Affiliations

Two different genes for X-linked retinitis pigmentosa

B Wirth et al. Genomics. 1988 Apr.

Abstract

Linkage analysis was carried out in three large multigenerational kindreds with X-linked retinitis pigmentosa using DNA markers on Xp. About 10% recombination has been found between the retinitis pigmentosa locus (RP2) and the marker locus DXS7, assigned to band Xp11.3, which was reported earlier to be closely linked to RP2 in several independent families. In the kindreds described in this paper, however, RP2 shows close linkage and no recombination with the marker loci OTC and DXS148, both assigned to Xp21, indicating that, contrary to previous linkage studies, there is evidence of an RP locus distal to DXS7. This suggests that X-linked retinitis pigmentosa is genetically heterogeneous, i.e., caused by mutations at different loci.

PubMed Disclaimer

Publication types

LinkOut - more resources