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Editorial
. 2021 May 11;143(19):1891-1893.
doi: 10.1161/CIRCULATIONAHA.121.054262. Epub 2021 May 10.

HDAC Inhibition in the Heart: Erasing Hidden Fibrosis

Thomas G Gillette  1
Affiliations
Editorial

HDAC Inhibition in the Heart: Erasing Hidden Fibrosis

Thomas G Gillette. Circulation. .
No abstract available

Keywords: Editorials; heart failure; histone deacetylases.

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Figures

Figure 1.
Figure 1.. The multifaceted impact of HDAC inhibition on heart pathology.
Red text depict processes inhibited and green text depict processes enhanced by HDAC inhibition. See text for details.
See this image and copyright information in PMC

Comment on

References

    1. Rothbart SB and Strahl BD. Interpreting the language of histone and DNA modifications. Biochim Biophys Acta. 2014;1839:627–43. - PMC - PubMed
    1. Gillette TG and Hill JA. Readers, writers, and erasers: chromatin as the whiteboard of heart disease. Circ Res. 2015;116:1245–53. - PMC - PubMed
    1. Ho TCS, Chan AHY and Ganesan A. Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight. J Med Chem. 2020;63:12460–12484. - PubMed
    1. Kee HJ, Sohn IS, Nam KI, Park JE, Qian YR, Yin Z, Ahn Y, Jeong MH, Bang YJ, Kim N, Kim JK, Kim KK, Epstein JA and Kook H. Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation. 2006;113:51–9. - PubMed
    1. Kong Y, Tannous P, Lu G, Berenji K, Rothermel BA, Olson EN and Hill JA. Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy. Circulation. 2006;113:2579–88. - PMC - PubMed

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