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Review
. 2021 May:67:103365.
doi: 10.1016/j.ebiom.2021.103365. Epub 2021 May 7.

Circulating extracellular vesicles are effective biomarkers for predicting response to cancer therapy

E Zhou  1 , Yumei Li  1 , Feng Wu  1 , Mengfei Guo  1 , Juanjuan Xu  1 , Sufei Wang  1 , Qi Tan  1 , Pei Ma  1 , Siwei Song  1 , Yang Jin  2
Affiliations
Review

Circulating extracellular vesicles are effective biomarkers for predicting response to cancer therapy

E Zhou et al. EBioMedicine. 2021 May.

Abstract

Cancer remains one of the most challenging diseases, as many patients show limited therapeutic response to treatment. Liquid biopsy is a minimally invasive method that has the advantage of providing real-time disease information with the least damage to cancer patients. Extracellular vesicles (EVs) released by the parental cells and protected by lipid bilayer membrane structure represent an emerging liquid biopsy modality. Apart from promoting cell growth, proliferation, and migration, EVs and their cargos (mainly miRNAs and proteins) are also biomarkers for cancer diagnosis and prognosis. Furthermore, their alterations pre- and post-therapy can guide therapeutic strategy determinations for better-stratified therapy. In this review, we summarize the potential clinical significance of EVs and their cargos in therapeutic response monitoring and prediction in several cancers (mainly lung cancer, prostate cancer, breast cancer, melanoma, lymphoma, glioblastoma, and head and neck squamous cell carcinoma) and discuss the questions that require future investigation.

Keywords: Biomarkers; Cancer; Extracellular vesicles; Liquid biopsy; Therapeutic response.

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Conflict of interest statement

Declaration of Competing Interest The authors declare no conflicts of interest.

Figures

Fig 1
Fig. 1
The strengths and limitations of circulating biomarkers in cancer. Circulating tumour cells (CTCs), circulating DNA (mainly circulating tumour DNA, ctDNA), circulating RNA (miRNA, mRNA, etc.), circulating proteins (e.g., carcinoma embryonic antigen, CEA; carbohydrate antigen 19–9, CA19–9) and circulating extracellular vesicles (EVs) are important biomarkers for therapy response evaluation.
Fig 2
Fig. 2
Biogenesis of exosomes and microvesicles. Exosomes are packaged in the late endosome and generated by the fusion of multivesicular bodies (MVBs) with plasma membrane. Microvesicles (MVs) usually refer to vesicles budding/blebbing from the plasma membrane. In addition, ectosomes, membrane particles, exosome-like vesicles, and apoptotic vesicles are also components of extracellular vesicles (EVs) with different size.
See this image and copyright information in PMC

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