Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jun;17(6):1563-1564.
doi: 10.1080/15548627.2021.1924501. Epub 2021 May 10.

PRKA/PKA signals and autophagy: space matters

Liliana Felicia Iannucci  1   2 , Giulietta Di Benedetto  2   3 , Konstantinos Lefkimmiatis  1   2
Affiliations
Comment

PRKA/PKA signals and autophagy: space matters

Liliana Felicia Iannucci et al. Autophagy. 2021 Jun.

Abstract

Macroautophagy/autophagy is the cellular process responsible for the elimination and recycling of aggregated proteins and damaged organelles. Whereas autophagy is strictly regulated by several signaling cascades, the link between this process and the subcellular distribution of its regulatory pathways remains to be established. Our recent work suggests that the compartmentalization of PRKA/PKA (protein kinase cAMP-activated) determines its effects on autophagy. We found that increased cAMP levels generate dramatically different PRKA activity "signatures" mainly dependent on the actions of phosphatases and the distribution of the PRKA holoenzymes containing type II regulatory subunits (PRKAR2A and PRKAR2B; RII). In this punctum we discuss how compartmentalized PRKA signaling events are generated and affect the autophagic flux in specific cell types.

Keywords: PKA; PRKA; autophagy; cAMP; compartmentalization; phosphatases.

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
PRKA-dependent phosphorylation is curbed in the cytosol by soluble phosphatases, which are less efficient in affecting PRKA targets that are phosphorylated near membranes. The local increase of PRKA target phosphorylation facilitates the autophagic process. The PRKA microdomain(s) directly involved in the regulation of autophagy remains to be established. ER: endoplasmic reticulum. Image created with BioRender.com
See this image and copyright information in PMC

Comment on

  • PKA compartmentalization links cAMP signaling and autophagy.
    Grisan F, Iannucci LF, Surdo NC, Gerbino A, Zanin S, Di Benedetto G, Pozzan T, Lefkimmiatis K. Grisan F, et al. Cell Death Differ. 2021 Aug;28(8):2436-2449. doi: 10.1038/s41418-021-00761-8. Epub 2021 Mar 19. Cell Death Differ. 2021. PMID: 33742135 Free PMC article.

References

    1. Grisan F, Iannucci LF, Surdo NC, et al. PKA compartmentalization links cAMP signaling and autophagy. Cell Death Differ. 2021. DOI:10.1038/s41418-021-00761-8 - DOI - PMC - PubMed

Publication types

LinkOut - more resources