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. 2021 May 10;21(1):531.
doi: 10.1186/s12885-021-08243-3.

Potential prognostic factors in progression-free survival for patients with cervical cancer

Hui-Hui Chen #  1 , Wei-Yu Meng #  2 , Run-Ze Li #  2 , Qing-Yi Wang  1 , Yu-Wei Wang  2 , Hu-Dan Pan  2 , Pei-Yu Yan  2 , Qi-Biao Wu  2 , Liang Liu  2 , Xiao-Jun Yao  3 , Min Kang  4 , Elaine Lai-Han Leung  5   6
Affiliations

Potential prognostic factors in progression-free survival for patients with cervical cancer

Hui-Hui Chen et al. BMC Cancer. .

Abstract

Background: Cervical cancer continues to be one of the leading causes of cancer deaths among females in low and middle-income countries. In this study, we aimed to assess the independent prognostic value of clinical and potential prognostic factors in progression-free survival (PFS) in cervical cancer.

Methods: We conducted a retrospective study on 92 cervical cancer patients treated from 2017 to 2019 at the Zhuhai Hospital of Traditional Chinese and Western Medicine. Tumor characteristics, treatment options, progression-free survival and follow-up information were collected. Kaplan-Meier method was used to assess the PFS.

Results: Results showed that the number of retrieved lymph nodes had a statistically significant effect on PFS of cervical cancer patients (P = 0.002). Kaplan-Meier survival curve analysis showed that cervical cancer patients with initial symptoms age 25-39 had worse survival prognoses (P = 0.020). And the using of uterine manipulator in laparoscopic treatment showed a better prognosis (P < 0.001). A novel discovery of our study was to verify the prognostic values of retrieved lymph nodes count combining with FIGO staging system, which had never been investigated in cervical cancer before. According to the Kaplan-Meier survival curve analysis and receiver operating characteristic (ROC) curve analysis, significant improvements were found after the combination of retrieved lymph nodes count and FIGO stage in predicting PFS for cervical cancer patients (P < 0.001, AUC = 0.826, 95% CI: 0.689-0.962).

Conclusion: Number of retrieved lymph nodes, initial symptoms age, uterine manipulator, and retrieved lymph nodes count combining with FIGO staging system could be potential prognostic factors for cervical cancer patients.

Keywords: Cervical cancer; FIGO staging; Progression-free survival; Retrieved lymph nodes count.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Kaplan-Meier curves of PFS in patients with cervical cancer. (a): Initial symptom age; (b): Tumor stage; (c): Retrieved lymph nodes count; (d): Uterine manipulator. PFS, progression-free survival
Fig. 2
Fig. 2
Kaplan-Meier curves of PFS related to the combination of retrieved lymph nodes count and FIGO stage of cervical cancer patients. PFS, progression-free survival. FIGO, International Federation of Gynecology and Obstetrics
Fig. 3
Fig. 3
ROC curves of retrieved lymph nodes count and FIGO staging classification. a: Combination of retrieved lymph nodes count and FIGO staging classification; b: FIGO staging classification. ROC, receiver operating characteristic. FIGO, International Federation of Gynecology and Obstetrics
See this image and copyright information in PMC

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