Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul 15;89(8):e0017421.
doi: 10.1128/IAI.00174-21. Epub 2021 Jul 15.

Risky Business: Oropharyngeal Bacteria Linked to Risk for Invasive Fungal Infection

Anna Dongari-Bagtzoglou  1
Affiliations

Risky Business: Oropharyngeal Bacteria Linked to Risk for Invasive Fungal Infection

Anna Dongari-Bagtzoglou. Infect Immun. .

Abstract

This work combines a clinical investigation with a mouse model of fungal infection to study the role of bacterial microbiota in fungal invasion. The investigators identified a dysbiosis in the oropharyngeal mucosa that was associated with a high risk for invasive infection in hematologic oncology patients. This study builds on our current understanding that the pathogenesis of fungal infections has to be studied in the context of a specific host background and a site-specific bacterial microbiota.

Keywords: dysbiosis.

PubMed Disclaimer

Comment on

  • Infect Immun. 89.

Similar articles

See all similar articles

References

    1. Costantini C, Nunzi E, Spolzino A, Palmieri M, Renga G, Zelante T, Englmaier L, Coufalikova K, Spáčil Z, Borghi M, Bellet MM, Acerbi E, Puccetti M, Giovagnoli S, Spaccapelo R, Talesa VN, Lomurno G, Merli F, Facchini L, Spadea A, Melillo L, Codeluppi K, Marchesi F, Marchesini G, Valente D, Dragonetti G, Nadali G, Pagano L, Aversa F, Romani L. 2021. Pharyngeal microbial signatures are predictive of the risk of fungal pneumonia in hematologic patients. Infect Immun 89:e00105-21. doi:10.1128/IAI.00105-21. - DOI - PMC - PubMed
    1. Pagano L, Busca A, Candoni A, Cattaneo C, Cesaro S, Fanci R, Nadali G, Potenza L, Russo D, Tumbarello M, Nosari A, Aversa F, et al. 2017. Risk stratification for invasive fungal infections in patients with hematological malignancies: SEIFEM recommendations. Blood Rev 31:17–29. doi:10.1016/j.blre.2016.09.002. - DOI - PubMed
    1. Zhai B, Ola M, Rolling T, Tosini NL, Joshowitz S, Littmann ER, Amoretti LA, Fontana E, Wright RJ, Miranda E, Veelken CA, Morjaria SM, Peled JU, Van den Brink MR, Babady NE, Butler G, Taur Y, Hohl TM. 2020. High-resolution mycobiota analysis reveals dynamic intestinal translocation prior to invasive candidiasis. Nat Med 26:59–64. doi:10.1038/s41591-019-0709-7. - DOI - PMC - PubMed
    1. Hong BY, Sobue T, Choquette L, Dupuy AK, Thompson A, Burleson JA, Salner AL, Schauer PK, Joshi P, Fox E, Shin DG, Weinstock GM, Strausbaugh LD, Dongari-Bagtzoglou A, Peterson DE, Diaz PI. 2019. Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis. Microbiome 7:66. doi:10.1186/s40168-019-0679-5. - DOI - PMC - PubMed
    1. Shelburne SA, Ajami NJ, Chibucos MC, Beird HC, Tarrand J, Galloway-Pena J, Albert N, Chemaly RF, Ghantoji SS, Marsh L, Pemmaraju N, Andreeff M, Shpall EJ, Wargo JA, Rezvani K, Alousi A, Bruno VM, Futreal PA, Petrosino JF, Kontoyiannis DP. 2015. Implementation of a pan-genomic approach to investigate holobiont-infecting microbe interaction: a case report of a leukemic patient with invasive mucormycosis. PLoS One 10:e0139851. doi:10.1371/journal.pone.0139851. - DOI - PMC - PubMed

Publication types

LinkOut - more resources