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Comment
. 2021 May 25;118(21):e2105040118.
doi: 10.1073/pnas.2105040118.

Reply to Cheng et al.: COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling

Sujin Kang  1 , Toshio Tanaka  2 , Hitomi Inoue  1 , Chikako Ono  3 , Shoji Hashimoto  4 , Yoshiyuki Kioi  1 , Hisatake Matsumoto  5 , Hiroshi Matsuura  5 , Tsunehiro Matsubara  5 , Kentaro Shimizu  5 , Hiroshi Ogura  5 , Yoshiharu Matsuura  5 , Tadamitsu Kishimoto  6
Affiliations
Comment

Reply to Cheng et al.: COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling

Sujin Kang et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no competing interest.

Comment on

References

    1. Cheng L., et al. ., COVID-19 induces lower levels of IL-8, IL-10, and MCP-1 than other acute CRS-inducing diseases. Proc. Natl. Acad. Sci. U.S.A., 10.1073/pnas.2102960118 (2021). - DOI - PMC - PubMed
    1. Kang S., et al. ., IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome. Proc. Natl. Acad. Sci. U.S.A. 117, 22351–22356 (2020). - PMC - PubMed
    1. Leisman D. E., et al. ., Cytokine elevation in severe and critical COVID-19: A rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir. Med. 8, 1233–1244 (2020). - PMC - PubMed
    1. Varga Z., et al. ., Endothelial cell infection and endotheliitis in COVID-19. Lancet 395, 1417–1418 (2020). - PMC - PubMed
    1. Ackermann M., et al. ., Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N. Engl. J. Med. 383, 120–128 (2020). - PMC - PubMed

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