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. 2021 Jun;18(6):1610-1612.
doi: 10.1038/s41423-021-00688-7. Epub 2021 May 10.

New insights into follicular helper T cell response and regulation in autoimmune pathogenesis

Affiliations

New insights into follicular helper T cell response and regulation in autoimmune pathogenesis

Fan Xiao et al. Cell Mol Immunol. 2021 Jun.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The regulation of Tfh responses in autoimmune pathogenesis. Tfh cells are regulated by various cell populations, including B cells, γδ T cells, Tfr cells, regulatory B cells and epithelial cells

References

    1. Deng J, Wei Y, Fonseca VR, Graca L, Yu D. T follicular helper cells and T follicular regulatory cells in rheumatic diseases. Nat. Rev. Rheumatol. 2019;15:475–490. doi: 10.1038/s41584-019-0254-2. - DOI - PubMed
    1. Kwok S-K, et al. A pathogenetic role for IL-21 in primary Sjögren syndrome. Nat. Rev. Rheumatol. 2015;11:368–374. doi: 10.1038/nrrheum.2014.225. - DOI - PubMed
    1. Fonseca VR, et al. The ratio of blood T follicular regulatory cells to T follicular helper cells marks ectopic lymphoid structure formation while activated follicular helper T cells indicate disease activity in primary Sjögren’s syndrome. Arthritis Rheumatol. 2018;70:774–784. doi: 10.1002/art.40424. - DOI - PubMed
    1. Li X, et al. Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjögren’s syndrome. Biochem Biophys. Res Commun. 2012;422:238–244. doi: 10.1016/j.bbrc.2012.04.133. - DOI - PubMed
    1. Kim J-W, et al. Circulating CCR7loPD-1hi follicular helper T cells indicate disease activity and glandular inflammation in patients with primary Sjögren’s syndrome. Immune Netw. 2019;19:e26. doi: 10.4110/in.2019.19.e26. - DOI - PMC - PubMed

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