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Case Reports
. 2021 Apr 8;13(4):e14364.
doi: 10.7759/cureus.14364.

Methotrexate Toxicity: A Simple Solution to a Complex Problem

Muhammad Asghar  1 , Hasan Shoaib  1 , Woosun Kang  1 , Irfa Tariq  2 , Tulika Chatterjee  1
Affiliations
Case Reports

Methotrexate Toxicity: A Simple Solution to a Complex Problem

Muhammad Asghar et al. Cureus. .

Abstract

Methotrexate is a highly effective medication that is the mainstay of treatment for numerous complex dermatological and rheumatological disorders. However, its use requires close monitoring as it has serious side effects that could be fatal if not recognized promptly. Herein, we present an interesting case of methotrexate toxicity leading to a prolonged hospital stay with resultant increase in health care cost and patient dissatisfaction. It remains of pivotal importance for primary care physicians and hospitalists to be aware of its side effect profile. As such, early recognition of methotrexate toxicity can result in earlier initiation of goal-directed therapies, leading to improved outcomes and shorter hospital stay. Patient education and effective communication between health care providers and the patient are of utmost importance in ensuring patient safety.

Keywords: cost-effective; drug rash; methotrexate toxicity; neutropenia; patient-centered care.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Rash involving the periumbilical and groin regions
Figure 2
Figure 2. Improvement in the rash after treatment
See this image and copyright information in PMC

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