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. 2021 Nov;29(11):6713-6719.
doi: 10.1007/s00520-021-06275-w. Epub 2021 May 10.

Quality of life in cancer patients with or without medication-related osteonecrosis of the jaw

Sara de Cassia Tornier  1 , Fernanda Joly Macedo  2 , Laurindo Moacir Sassi  2 , Juliana Lucena Schussel  3   4
Affiliations

Quality of life in cancer patients with or without medication-related osteonecrosis of the jaw

Sara de Cassia Tornier et al. Support Care Cancer. 2021 Nov.

Abstract

Purpose: Cancer and its therapies can have a significant impact on general and oral health and, therefore, cause a reduction in patients' quality of life (QoL). The study aimed to evaluate the QoL of cancer patients who use antiresorptive and anti-angiogenic medications with or without the development of medication-related osteonecrosis of the jaws (MRONJ).

Methods: Sixty-two patients diagnosed with cancer under antiresorptive therapy answered three instruments from the European Organization for Cancer Research and Treatment (EORTC). The first questionnaire (QLQ-C30) aimed to measure the overall QoL, the second (QLQ-ELD14) is a complementary module for elderly patients, and the third (QLQ-OH15) aimed to assess oral health related to QoL.

Results: The mean age of the patients was 62.19 years, and 12.9% developed MRONJ. There was no significant difference between sex and MRONJ. Among the QLQ-C30 scales, the item "role functioning (RF2)" presented a significant result (p = 0.019). Those patients without MRONJ had a better function performance both in their daily chores and in their free time. Age was not associated to MRONJ, although some concerns are common to the elderly and cancer patients. QoL related to oral health presented a significant result (p = 0.048) showing that MRONJ has a negative impact on patients' QoL.

Conclusion: Our results showed that MRONJ has a significant impact on the general and oral QoL of cancer patients, and therefore prevention and awareness must be a priority.

Keywords: Medication-related osteonecrosis of the jaws; Oral health; Quality of life.

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