Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;38(1):105-113.
doi: 10.1007/s11282-021-00532-8. Epub 2021 May 11.

Brachytherapy with 198Au grains for cancer of the floor of the mouth: relationships between radiation dose and complications

Masaru Konishi  1 , Yuki Takeuchi  2 , Nobuki Imano  2 , Katsumaro Kubo  2 , Ikuno Nishibuchi  2 , Yuji Murakami  2 , Kiichi Shimabukuro  3 , Pongsapak Wongratwanich  3 , Naoya Kakimoto  3 , Yasushi Nagata  3
Affiliations

Brachytherapy with 198Au grains for cancer of the floor of the mouth: relationships between radiation dose and complications

Masaru Konishi et al. Oral Radiol. 2022 Jan.

Abstract

Objective: This study aimed to retrospectively evaluate the radiation dose and complications in soft tissue and mandible caused by 198Au grain brachytherapy alone or the combination with other modalities in patients with the cancer of the floor of the mouth.

Materials and methods: Twelve patients with T1 (n = 5) and T2 (n = 7) squamous cell carcinoma of the floor of the mouth, who were treated with 198Au grain brachytherapy alone (n = 5) or the combination of external beam radiotherapy (EBRT) and/or chemotherapy and 198Au grain brachytherapy (n = 7) from January 2005 to December 2016, were included. The relationships between the radiation dose and the complications of the soft tissue or mandible were investigated.

Results: Seven of 12 patients had died. Of these 7 patients, one with T1 and 2 with T2 had died of the causes related to the cancer of the floor of the mouth. Two with T1 and 2 with T2 had died of other diseases. Two patients had grade 2 complications of the soft tissue and mandible. These patients were treated by the combination of EBRT and/or chemotherapy and 198Au grain brachytherapy and irradiated with 123 or 139 Gy in total dose, respectively. And one of these patients was treated by the chemotherapy in addition to EBRT.

Conclusion: Our study showed that the combination of EBRT and 198Au grains brachytherapy for the floor of the mouth cancer patients might be associated with risks of developing complications of soft tissue ulcer and mandibular bone necrosis.

Keywords: 198Au grain; Brachytherapy; Floor of mouth; Osteoradionecrosis; Ulcer.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Shibuya H, Hoshina M, Takeda M, Matsumoto S, Suzuki S, Okada N. Brachytherapy for stage I & II oral tongue cancer: an analysis of past cases focusing on control and complications. Int J Radiat Oncol Biol Phys. 1993;26:51–8. - DOI
    1. Tayier A, Hayashi K, Yoshimura R. Low-dose-rate interstitial brachytherapy preserves good quality of life in buccal mucosa cancer patients. J Radiat Res. 2011;52:655–9. - DOI
    1. Matsumoto S, Takeda M, Shibuya H, Suzuki S. T1 and T2 squamous cell carcinomas of the floor of the mouth: results of brachytherapy mainly using 198Au grains. Int J Radiat Oncol Biol Phys. 1996;34:833–41. - DOI
    1. Ryu Y, Shibuya H, Hayashi K. 198Au grain implantation for early tongue cancer in patients of advanced age or poor performance status. J Radiat Res. 2013;54:1125–30. - DOI
    1. Khalilur R, Hayashi K, Shibuya H. Brachytherapy for tongue cancer in the very elderly is an alternative to external beam radiation. Br J Radiol. 2011;84:747–9. - DOI

LinkOut - more resources