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. 2021 Nov;268(11):4152-4162.
doi: 10.1007/s00415-021-10491-z. Epub 2021 May 11.

Thalamic versus midbrain tremor; two distinct types of Holmes' Tremor: a review of 17 cases

N Nsengiyumva  1   2 , A Barakat  3 , A Macerollo  4 , R Pullicino  3 , A Bleakley  3 , M Bonello  4 , R J B Ellis  4 , S H Alusi  5
Affiliations

Thalamic versus midbrain tremor; two distinct types of Holmes' Tremor: a review of 17 cases

N Nsengiyumva et al. J Neurol. 2021 Nov.

Abstract

Introduction: Holmes Tremor (HT) is a unique and debilitating movement disorder. It usually results from lesions of the midbrain and its connection but can also result from posterior thalamic injury. Clinical examination can help lesion localization between these two areas. We studied the clinical features and their radiological correlations to distinguish midbrain HT (HT-m) from thalamic HT (HT-t).

Methods: Retrospective review of 17 patients with a HT-type presentation was conducted. Tremor characteristics, associated clinical signs and radiological findings were studied.

Results: Eleven patients had a myorythmic rest tremor, large amplitude proximal tremor with goal-directed worsening, with or without mild distal dystonic posturing, representing HT-m. Six patients had slow, large amplitude proximal tremors and distal choreathetoid movements, significant proximal/distal dystonic posturing, associated with proprioceptive sensory loss, representing HT-t. Haemorrhagic lesions were the predominant cause of HT-m; whereas, ischaemia was more commonly associated with HT-t.

Conclusion: When assessing patients with HT, attentiveness to the presence of associated signs in the affected limb, such as a proprioceptive sensory deficits and additional movement disorders, can aid lesion localisation, which can have implications for management.

Keywords: Holmes' Tremor; Stroke; Thalamic tremor.

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