Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021:1318:23-39.
doi: 10.1007/978-3-030-63761-3_2.

Coronaviruses: What Should We Know About the Characteristics of Viruses?

Wei Ji  1   2
Affiliations
Review

Coronaviruses: What Should We Know About the Characteristics of Viruses?

Wei Ji. Adv Exp Med Biol. 2021.

Abstract

The ongoing coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly contagious and fatal, posing a direct threat to human health and the global economy. Most strategies to prevent, control, and eradicate COVID-19 are established based on the specific characteristics of the pathogen. The quest for interruption and eradication of COVID-19 has moved research forward in understanding fundamental aspects of the virus genome, proteome, replication mechanisms, and virus-host interactions, which pave the way for the development of effective antiviral drugs and vaccines. This chapter provides an overview of recent progress in human coronavirus taxonomy, molecular features of the SARS-CoV-2 genome and proteome, and virus life cycle.

Keywords: COVID-19; Genome; Human coronavirus; Life cycle; SARS-CoV-2; Severe acute respiratory syndrome; Structural and nonstructural proteins; Taxonomy.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Abdul-Rasool S, Fielding BC (2010) Understanding human coronavirus HCoV-NL63. Open Virol J 4:76–84. https://doi.org/10.2174/1874357901004010076 - DOI - PubMed - PMC
    1. Adedeji AO, Marchand B, Te Velthuis AJW, Snijder EJ, Weiss S, Eoff RL, Singh K, Sarafianos SG (2012a) Mechanism of nucleic acid unwinding by SARS-CoV helicase. PLoS One 7(5):e36521–e36521. https://doi.org/10.1371/journal.pone.0036521 - DOI - PubMed - PMC
    1. Adedeji AO, Singh K, Sarafianos SG (2012b) Structural and biochemical basis for the difference in the helicase activity of two different constructs of SARS-CoV helicase. Cell Mol Biol (Noisy-le-Grand) 58(1):114–121
    1. Alhammad YMO, Kashipathy MM, Roy A, Johnson DK, McDonald P, Battaile KP, Gao P, Lovell S, Fehr AR (2020) The SARS-CoV-2 conserved macrodomain is a highly efficient ADP-ribosylhydrolase enzyme. bioRxiv:2020.2005.2011.089375. https://doi.org/10.1101/2020.05.11.089375
    1. Angeletti S, Benvenuto D, Bianchi M, Giovanetti M, Pascarella S, Ciccozzi M (2020) COVID-2019: the role of the nsp2 and nsp3 in its pathogenesis. J Med Virol 92(6):584–588. https://doi.org/10.1002/jmv.25719 - DOI - PubMed

Substances

LinkOut - more resources