Pharmacogenetic testing in psychiatry and neurology: an overview of reviews
- PMID: 33973477
- DOI: 10.2217/pgs-2020-0187
Pharmacogenetic testing in psychiatry and neurology: an overview of reviews
Abstract
Pharmacogenetic testing is available to healthcare professionals to guide drug selection and prevent adverse events. However, its implementation in the clinical practice of psychiatry/neurology still has barriers, mainly due to a lack of evidence. We conducted a literature search on Cochrane Library, Embase and Pubmed, from their inception to 18 June 2020. We included 16 published systematic reviews. The most studied drug categories were anticonvulsants and selective serotonin reuptake inhibitors associated with human leukocyte antigen and cytochrome P450 genes (HLA-A, HLA-B, CYP2C9, CYP2D6, CYP2C19), classified as critically low quality/low quality. There is a need for more robust studies with adequate design to assess the potential benefits of adopting pharmacogenetics in health systems and services.
Keywords: evidence-based medicine; neurology; pharmacogenetics; psychiatry; systematic review.
Similar articles
-
Towards the integration of pharmacogenetics in psychiatry: a minimum, evidence-based genetic testing panel.Curr Opin Psychiatry. 2019 Jan;32(1):7-15. doi: 10.1097/YCO.0000000000000465. Curr Opin Psychiatry. 2019. PMID: 30299306 Review.
-
Review and Consensus on Pharmacogenomic Testing in Psychiatry.Pharmacopsychiatry. 2021 Jan;54(1):5-17. doi: 10.1055/a-1288-1061. Epub 2020 Nov 4. Pharmacopsychiatry. 2021. PMID: 33147643
-
Pharmacogenetic testing-guided treatment for oncology: an overview of reviews.Pharmacogenomics. 2022 Aug;23(13):739-748. doi: 10.2217/pgs-2022-0064. Epub 2022 Aug 24. Pharmacogenomics. 2022. PMID: 36001087 Review.
-
Commercial Pharmacogenetic Tests in Psychiatry: Do they Facilitate the Implementation of Pharmacogenetic Dosing Guidelines?Pharmacopsychiatry. 2020 Jul;53(4):174-178. doi: 10.1055/a-0863-4692. Epub 2019 Mar 21. Pharmacopsychiatry. 2020. PMID: 30900236 Review.
-
Pharmacogenetics in psychiatric care, a call for uptake of available applications.Psychiatry Res. 2020 Oct;292:113336. doi: 10.1016/j.psychres.2020.113336. Epub 2020 Jul 27. Psychiatry Res. 2020. PMID: 32739644 Review.
Cited by
-
The Effect of Genotyping on the Number of Pharmacotherapeutic Gene-Drug Interventions in Chronic Kidney Disease Patients.Pharmacy (Basel). 2023 Apr 4;11(2):69. doi: 10.3390/pharmacy11020069. Pharmacy (Basel). 2023. PMID: 37104075 Free PMC article.
-
Ethnic Aspects of Valproic Acid P-Oxidation.Biomedicines. 2024 May 8;12(5):1036. doi: 10.3390/biomedicines12051036. Biomedicines. 2024. PMID: 38790997 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous