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Review
. 2021 Jun;22(8):505-513.
doi: 10.2217/pgs-2020-0187. Epub 2021 May 11.

Pharmacogenetic testing in psychiatry and neurology: an overview of reviews

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Review

Pharmacogenetic testing in psychiatry and neurology: an overview of reviews

Danilo Vieira de Lara et al. Pharmacogenomics. 2021 Jun.

Abstract

Pharmacogenetic testing is available to healthcare professionals to guide drug selection and prevent adverse events. However, its implementation in the clinical practice of psychiatry/neurology still has barriers, mainly due to a lack of evidence. We conducted a literature search on Cochrane Library, Embase and Pubmed, from their inception to 18 June 2020. We included 16 published systematic reviews. The most studied drug categories were anticonvulsants and selective serotonin reuptake inhibitors associated with human leukocyte antigen and cytochrome P450 genes (HLA-A, HLA-B, CYP2C9, CYP2D6, CYP2C19), classified as critically low quality/low quality. There is a need for more robust studies with adequate design to assess the potential benefits of adopting pharmacogenetics in health systems and services.

Keywords: evidence-based medicine; neurology; pharmacogenetics; psychiatry; systematic review.

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