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. 2021 Aug;23(8):1556-1566.
doi: 10.1111/jch.14267. Epub 2021 May 11.

Development of the prediction model for hypertension in patients with idiopathic inflammatory myopathies

Li Qin  1 , Yiwen Zhang  1 , Xiaoqian Yang  1 , Han Wang  1
Affiliations

Development of the prediction model for hypertension in patients with idiopathic inflammatory myopathies

Li Qin et al. J Clin Hypertens (Greenwich). 2021 Aug.

Abstract

Cardiac involvement is an important cause of morbidity and mortality in patients with idiopathic inflammatory myopathies (IIMs). Hypertension, an important cardiovascular risk factor for the general population, has a crucial role in heart involvement. However, few studies have focused on the hypertension associated with IIMs. This study aimed to develop and assess the prediction model for incident hypertension in patients with IIMs. A retrospective cohort study was performed on 362 patients with IIMs, of whom 54 (14.9%) were given a diagnosis of new-onset hypertension from January 2008 to December 2018. The predictors of hypertension in IIMs were selected by least absolute shrinkage and selection operator (LASSO) regression, multivariable logistic regression, and clinically relevance, and then these predictors were used to draw the nomogram. Discrimination, calibration and clinical usefulness of the model were evaluated using the C-index, calibration plot, and decision curve analysis, respectively. The predicting model was validated by the bootstrapping validation. The nomogram mainly included predictors such as age, diabetes mellitus, triglyceride, low-density lipoprotein-cholesterol (LDL-C), antinuclear antibodies (ANA), and smoking. This prediction model demonstrated good discrimination with a C-index of 0.754 (95%CI, 0.684 to 0.824) and good calibration. The C-index of internal validation was 0.728, and decision curve analysis demonstrated that this nomogram was clinically useful. Clinicians can use this prediction model to assess the risk of hypertension in IIMs patients, and early preventive measures should be taken to reduce the incidence of hypertension in high-risk patients.

Keywords: hypertension; idiopathic inflammatory myopathies; nomogram; prediction model.

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Demographic and clinical features selection using the LASSO regression model
FIGURE 2
FIGURE 2
Developed prediction hypertension nomogram
FIGURE 3
FIGURE 3
Calibration curves of the prediction hypertension nomogram in the cohort
FIGURE 4
FIGURE 4
Decision curve analysis for the prediction hypertension nomogram
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