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Comment
. 2021 May 10;39(5):596-598.
doi: 10.1016/j.ccell.2021.03.011.

NRF2 activates macropinocytosis upon autophagy inhibition

Gourish Mondal  1 , Jayanta Debnath  2
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Free article
Comment

NRF2 activates macropinocytosis upon autophagy inhibition

Gourish Mondal et al. Cancer Cell. .
Free article

Abstract

Su et al. demonstrate that upon inhibiting autophagy, an intracellular nutrient recycling pathway, pancreatic ductal adenocarcinoma cells upregulate NRF2-mediated transcription of macropinocytosis pathway components, thereby triggering an alternate route for tumors to scavenge nutrients from extracellular sources. Accordingly, the combined inhibition of autophagy and macropinocytosis may improve cancer treatment.

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Conflict of interest statement

Declaration of interests J.D. is a Scientific Advisory Board member for Vescor Therapeutics, L.L.C.

Comment on

  • Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis.
    Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. Su H, et al. Cancer Cell. 2021 May 10;39(5):678-693.e11. doi: 10.1016/j.ccell.2021.02.016. Epub 2021 Mar 18. Cancer Cell. 2021. PMID: 33740421 Free PMC article.

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