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Meta-Analysis
. 2021 May 11;21(1):247.
doi: 10.1186/s12888-021-03244-9.

Lower regional grey matter in alcohol use disorders: evidence from a voxel-based meta-analysis

Lei Li #  1   2   3 , Hua Yu #  1   2   3 , Yihao Liu  4 , Ya-Jing Meng  1   2   3 , Xiao-Jing Li  1   2   3 , Chengcheng Zhang  1   2   3 , Sugai Liang  1   2   3 , Ming-Li Li  1   2   3 , Wanjun Guo  1   2   3 , QiangWang  1   2   3 , Wei Deng  1   2   3 , Xiaohong Ma  1   2   3 , Jeremy Coid  1   2   3 , Tao Li  5   6   7
Affiliations
Meta-Analysis

Lower regional grey matter in alcohol use disorders: evidence from a voxel-based meta-analysis

Lei Li et al. BMC Psychiatry. .

Abstract

Background: Previous research using whole-brain neuroimaging techniques has revealed structural differences of grey matter (GM) in alcohol use disorder (AUD) patients. However, some of the findings diverge from other neuroimaging studies and require further replication. The quantity of relevant research has, thus far, been limited and the association between GM and abstinence duration of AUD patients has not yet been systematically reviewed.

Methods: The present research conducted a meta-analysis of voxel-based GM studies in AUD patients published before Jan 2021. The study utilised a whole brain-based d-mapping approach to explore GM changes in AUD patients, and further analysed the relationship between GM deficits, abstinence duration and individual differences.

Results: The current research included 23 studies with a sample size of 846 AUD patients and 878 controls. The d-mapping approach identified lower GM in brain regions including the right cingulate gyrus, right insula and left middle frontal gyrus in AUD patients compared to controls. Meta-regression analyses found increasing GM atrophy in the right insula associated with the longer mean abstinence duration of the samples in the studies in our analysis. GM atrophy was also found positively correlated with the mean age of the samples in the right insula, and positively correlated with male ratio in the left middle frontal gyrus.

Conclusions: GM atrophy was found in the cingulate gyrus and insula in AUD patients. These findings align with published meta-analyses, suggesting they are potential deficits for AUD patients. Abstinence duration, age and gender also affect GM atrophy in AUD patients. This research provides some evidence of the underlying neuroanatomical nature of AUD.

Keywords: Abstinence; Alcohol use disorders; Grey matter; Meta-analysis; Voxel-based morphometry.

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Conflict of interest statement

No conflicts of interest declared by any author.

Figures

Fig. 1
Fig. 1
Flowchart of the selection of VBM studies in patients with AUD for meta-analysis
Fig. 2
Fig. 2
Meta-analysis results. a Regions showed lower GM in AUD patients than controls. b Meta-regression analysis indicated that GM in the right insula was significantly negatively associated with duration of abstinence in AUD patients. c Meta-regression analysis indicated that GM in the right insula was significantly negatively associated with mean age in AUD patients. d Meta-regression analysis showed that GM in the left middle frontal gyrus was significantly negatively associated with male ratio in AUD patients. Blue colour represents GM reduction
See this image and copyright information in PMC

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References

    1. Leshner AI. Addiction is a brain disease, and it matters. Science. 1997;278(5335):45–47. doi: 10.1126/science.278.5335.45. - DOI - PubMed
    1. Koob GF. The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction. 2006;101(Suppl 1):23–30. doi: 10.1111/j.1360-0443.2006.01586.x. - DOI - PubMed
    1. Wise RA. Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotox Res. 2008;14(2–3):169–183. doi: 10.1007/BF03033808. - DOI - PMC - PubMed
    1. Volkow ND, Swanson JM, Evins AE, DeLisi LE, Meier MH, Gonzalez R, Bloomfield MA, Curran HV, Baler R. Effects of Cannabis use on human behavior, including cognition, motivation, and psychosis: a review. JAMA Psychiatr. 2016;73(3):292–297. doi: 10.1001/jamapsychiatry.2015.3278. - DOI - PubMed
    1. Gröpper S, Spengler S, Stuke H, Gawron CK, Parnack J, Gutwinski S, Wiers CE, Bermpohl F. Behavioral impulsivity mediates the relationship between decreased frontal gray matter volume and harmful alcohol drinking: a voxel-based morphometry study. J Psychiatr Res. 2016;83(Complete):16–23. doi: 10.1016/j.jpsychires.2016.08.006. - DOI - PubMed

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