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Randomized Controlled Trial
. 2021 May 11;11(1):9933.
doi: 10.1038/s41598-021-89541-5.

Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer

Wei Ge #  1 , Qiang Li #  1 , Wen-Jia Liu  2 , Xiao-Qi Zhang  2 , Xiang-Shan Fan  3 , Li-Hua Shao  1 , Liang Tao  1 , Wen-Xian Guan  4 , Gang Chen  5
Affiliations
Randomized Controlled Trial

Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer

Wei Ge et al. Sci Rep. .

Abstract

This study aimed to evaluate whether carbon nanoparticles could improve the accuracy of nodal staging in colorectal cancer (CRC). We performed a randomized controlled trial with CRC at the department of general surgery, the affiliated hospital of Nanjing University Medical School. A total of 160 patients were recruited in this research and 132 patients were included in the safety analyses. Among these patients, 72 cases were classified into control group and 60 cases into study group. The mean number of lymph nodes harvested from patients in study group was 19.3 ± 6.7 (range from 4 to 38), which was higher than that in control group (15.1 ± 5.7 (range from 3 to 29)) (p < 0.001). The mean number of positive lymph nodes got from patients in study group was 1.7 ± 3.5 (range from 0 to 22), which was also higher than that in control group (0.7 ± 1.4 (range from 0 to 7)) (p = 0.045). In study group, there were 30 patients (50%) proved to be N0, and remaining 30 patients (50%) were N1 or N2. However, 50 patients (69.4%) were N0 and 22 patients (30.6%) were N1 or N2 in control group. The rate of N0 in control group was significantly higher than that in study group (p = 0.023). Injecting carbon nanoparticle suspension could get a more accurate nodal staging to receive enough chemoradiotherapy, improving prognosis. Besides, injecting carbon nanoparticles suspension at four points 5 cm, 10 cm, 15 cm and 20 cm away from the anus by "sandwich" method was a new try.Trial registration: This study was registered with ClinicalTrials.gov, number ChiCTR1900025127 on 12/8/2019.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Trial profile.
Figure 2
Figure 2
The lymph node was dyed black by carbon nanoparticle suspension during operation (A); we could get the lymph nodes from the specimen easily.
Figure 3
Figure 3
The constituent ratios of N0, N1, and N2 in study and control groups without statistic difference (P = 0.071).
See this image and copyright information in PMC

References

    1. Tang JWC, Lam WWT, Ma ASY, Law WL, Wei R, Fielding R. Dietary changes adopted by Chinese colorectal cancer patients: A qualitative study. Eur. J. Cancer Care. 2019;30:e13159. - PubMed
    1. Wieldraaijer T, de Meij M, Zwaard S, van Weert H, Wind J. Introducing a time out consultation with the general practitioner between diagnosis and start of colorectal cancer treatment: Patient-reported outcomes. Eur. J. Cancer Care. 2019;30:e13141. - PMC - PubMed
    1. Betge J, Harbaum L, Pollheimer MJ, Lindtner RA, Kornprat P, Ebert MP, et al. Lymph node retrieval in colorectal cancer: Determining factors and prognostic significance. Int. J. Colorectal Dis. 2017;32(7):991–998. doi: 10.1007/s00384-017-2778-8. - DOI - PMC - PubMed
    1. Balducci G, Sederino MG, Laforgia R, Carbotta G, Minafra M, Delvecchio A, et al. Lymph node assessment in colorectal cancer surgery: Laparoscopic versus open techniques. G Chir. 2017;38(1):23–26. doi: 10.11138/gchir/2017.38.1.023. - DOI - PMC - PubMed
    1. Nelson H, Petrelli N, Carlin A, Couture J, Fleshman J, Guillem J, Miedema B, Ota D, Sargent D, National Cancer Institute Expert Panel Guidelines 2000 for colon and rectal cancer surgery. J. Natl. Cancer Inst. 2001;93(8):583–596. doi: 10.1093/jnci/93.8.583. - DOI - PubMed

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