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Review
. 2021;59(2):104-110.
doi: 10.5114/reum.2021.105418. Epub 2021 Apr 27.

Clinical manifestations of Whipple's disease mimicking rheumatic disorders

Eugeniusz J Kucharz  1 , Justyna Kramza  1 , Anida Grosicka  1 , Robert Pieczyrak  1
Affiliations
Review

Clinical manifestations of Whipple's disease mimicking rheumatic disorders

Eugeniusz J Kucharz et al. Reumatologia. 2021.

Abstract

Whipple's disease is a rare, chronic, systemic disorder caused by Tropheryma whipplei infection. The most common symptoms are weight loss, arthralgia, diarrhea and abdominal pain. Other organ involvement can also occur in the patients. Joint manifestations may mimic rheumatoid arthritis or spondyloarthritis. Arthalgia, arthritis, spondylodiscitis, bursitis and/or tenosynovitis are seen in the majority of the patients. This explains why some of the symptoms are misdiagnosed as those of rheumatic diseases. Understanding of Whipple's disease is important for differential diagnostics of several rheumatic symptoms.

Keywords: Whipple’s disease; arthritis; spondylodiscitis.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Allchin WH, Hebb RG. Lymphangiectasis intestine. Trans Path Soc (London) 1895;46:221–223.
    1. Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp. 1907;18:3582–391.
    1. Black-Schaffer B. The tinctorial demonstration of a glycoprotein in Whipple’s disease. Proc Soc Exp Biol Med. 1949;72:225–227. - PubMed
    1. Paulley JW. A case of Whipple’s disease (interstinal lipodystrophy) Gastroenterology. 1952;22:128–132. - PubMed
    1. Cohen AS, Schimmel EM, Holt PR, Isselbacher KJ. Ultrastructural abnormalities in Whipple’s disease. Proc Soc Exp Biol Med. 1960;105:411–414. doi: 10.3181/00379727-105-26126. - DOI - PubMed

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