Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 23:2021:6616886.
doi: 10.1155/2021/6616886. eCollection 2021.

Opposing and Operated Side Electroacupuncture Generates Similar Analgesic Effects on Pain after Knee Surgery

Hai Huang  1 , Xiuling Song  2 , Jiayou Wang  2 , Man Xing  2 , Bingxin Kang  3 , Chenghao Ma  3 , Wenbiao Li  2 , Wenjun Han  2 , Lianbo Xiao  3 , Yuelai Chen  2
Affiliations

Opposing and Operated Side Electroacupuncture Generates Similar Analgesic Effects on Pain after Knee Surgery

Hai Huang et al. Evid Based Complement Alternat Med. .

Abstract

The purpose of this study was to investigate whether opposing electroacupuncture (EA) could produce similar analgesic effects as operated side EA after knee surgery in rats. Sprague Dawley rats were randomly divided into the sham surgery group, and three surgery groups: opposing EA, operated side EA, and model. After surgery, compared with the sham surgery group, three kinds of pain behavior test methods (mechanical withdrawal threshold (MWT), cumulative pain score [CPS], and mechanical hypersensitivity of knee) were used to assess the pain behavior of the rats in the surgery groups. After knee surgery, the three surgery groups were intervened for three consecutive days: EA on the nonoperated side in the opposing EA group, EA on the operated side in the operated side EA group, and no intervention in the model group. It was shown that MWT was higher and CPS was lower in the two EA groups than in the model group on the first and second days after surgery. On the third day after surgery, MWT in the two EA groups was the highest among the 3 days, CPS was the lowest among the 3 days, and the number of nonvocalizations in rats also increased compared with the model group. Moreover, the MWT of the nonoperated side increased more in the opposing EA group than in the model and operated side EA groups. This indicated that both opposing EA and operated side EA methods can be used to relieve pain after knee joint surgery.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest and no financial interests regarding the publication of this article.

Figures

Figure 1
Figure 1
Photographs of the procedure of KSM.
Figure 2
Figure 2
Experimental procedures, acupoints, and intervention. (a) Abbreviations: MWT, mechanical withdrawal threshold; CPS, cumulative pain score; MHK, mechanical hypersensitivity of knee. (b) SD rats received KSM on the right knee joint, EA on the the contralateral (left) side in opposing EA group, while EA on the operated (right) side in the operated side EA group. (c) The acupoints futu (ST32), housanli (ST36), and yangling quan (GB34) are located on lateral lower leg, yingling quan (SP9) on the medial lower leg, all are around the knee joint of rats.
Figure 3
Figure 3
Mechanical withdrawal threshold. Note.#P < 0.05 compared with sham surgery group; ∗P < 0.05 compared with the model group; &P < 0.05 compared with the operated side EA group.
Figure 4
Figure 4
CPS and number of nonvocalizations. Note.#P < 0.05 compared with the sham surgery group; ∗P < 0.05 compared with the model group.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Price A. J., Alvand A., Troelsen A., et al. Knee replacement. The Lancet. 2018;392(10158):1672–1682. doi: 10.1016/s0140-6736(18)32344-4. - DOI - PubMed
    1. Lin K., Bao L., Wang J., Fujita K., Makimoto K., Liao X. Validation of the Chinese (Mandarin) version of the oxford knee score in patients with knee osteoarthritis. Clinical Orthopaedics & Related Research. 2017;475(12):2992–3004. doi: 10.1007/s11999-017-5495-2. - DOI - PMC - PubMed
    1. Sloan M., Premkumar A., Sheth N. P. Projected volume of primary total joint arthroplasty in the U.S., 2014 to 2030. Journal of Bone and Joint Surgery. 2018;100(17):1455–1460. doi: 10.2106/jbjs.17.01617. - DOI - PubMed
    1. Gui Q., Zhang X., Liu L., Zhao F., Cheng W., Zhang Y. Cost-utility analysis of total knee arthroplasty for osteoarthritis in a regional medical center in China. Health Economics Review. 2019;9(1):p. 15. doi: 10.1186/s13561-019-0231-0. - DOI - PMC - PubMed
    1. Ong K. L., Niazi F., Lau E., et al. Knee OA cost comparison for hyaluronic acid and knee arthroplasty. Journal of Orthopaedic Surgery and Research. 2020;151(1):p. 305. - PMC - PubMed

LinkOut - more resources