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Review
. 2021 Jul:42:100895.
doi: 10.1016/j.nmni.2021.100895. Epub 2021 May 7.

A mini-review on sofosbuvir and daclatasvir treatment in coronavirus disease 2019

M Shabani  1 , B Sadegh Ehdaei  2 , F Fathi  3 , R Dowran  1
Affiliations
Review

A mini-review on sofosbuvir and daclatasvir treatment in coronavirus disease 2019

M Shabani et al. New Microbes New Infect. 2021 Jul.

Abstract

Sofosbuvir and daclatasvir have been used successfully since 2013 for hepatitis C treatment. It has been shown by different studies that sofosbuvir can inhibit RNA polymerase of other positive-strand RNA viruses including Flaviviridae and Togaviridae. Homology between hepatitis C virus RNA polymerase and severe acute respiratory syndrome coronavirus 2 has also been established. The efficacy of sofosbuvir and daclatasvir as potential choices in treating patients with coronavirus disease 2019 and their recovery can be hypothesized.

Keywords: COVID-19; HCV; SARS-CoV-2; daclatasvir; sofosbuvir.

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