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Meta-Analysis
. 2021 Apr 12:2021:5530149.
doi: 10.1155/2021/5530149. eCollection 2021.

Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Run Lin  1   2 , Shaoyang Cui  1 , Juan Yang  3 , Huijun Yang  1   2 , Zitong Feng  4 , Dietlind L Wahner-Roedler  3 , Xuan Zhou  5 , Manisha Salinas  6 , Molly J Mallory  3 , Alexander Do  3 , Sara E Bublitz  3 , Tony Y Chon  3 , Chunzhi Tang  4 , Brent A Bauer  3 , Mingzhu Xu  7
Affiliations
Meta-Analysis

Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Run Lin et al. Biomed Res Int. .

Retraction in

Abstract

Design: Randomized controlled trials (RCTs) from multiple databases from inception to December 2020 published in English were searched. Two researchers independently performed eligible study screening and data extraction. The methodological quality was assessed with the Jadad score. Meta-analysis of RCTs on TC in the treatment of MCI was performed with RevMan Version 5.4.1.

Results: Seven RCTs with 1265 participants were included. For most RCTs, the overall reporting of methodological quality was high. Results of the meta-analysis indicate that TC improved MCI patients' cognitive function significantly, including overall cognitive function (MD = -2.24, 95% CI -3.51 to -0.97, P = 0.0005), memory and learning (SMD = 0.83, 95% CI 0.22 to 1.45, P = 0.008), visuospatial ability (MD = 3.15, 95% CI 0.74 to 5.56, P = 0.01), executive functions (MD = 0.32, 95% CI 0.03 to 0.61, P = 0.03), and physical activity (MD = 18.78, 95% CI 10.80 to 26.76, P < 0.00001). However, no significant benefit was found for TC on psychological activity (MD = 0.17, 95% CI -0.62 to 0.96, P = 0.36) and biomarker improvement.

Conclusion: The meta-analysis confirmed the clinical therapeutic effect of TC for MCI. More rigorous and long-term follow-up RCTs should be conducted in the future.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram for study selection process.
Figure 2
Figure 2
Risk of bias for each included study.
Figure 3
Figure 3
Forest plot for Tai Chi on global cognitive function.
Figure 4
Figure 4
Forest plot for Tai Chi on memory and learning.
Figure 5
Figure 5
Forest plot for Tai Chi on visuospatial ability.
Figure 6
Figure 6
Forest plot for Tai Chi on executive function.
Figure 7
Figure 7
Forest plot for Tai Chi on physical activity.
Figure 8
Figure 8
Forest plot for Tai Chi on psychological activity.
See this image and copyright information in PMC

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