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Review
. 2021 May 7;4(2):e282.
doi: 10.1002/hsr2.282. eCollection 2021 Jun.

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Mohammad Rafiee  1   2 , Mohammad Abbasi  3 , Hassan Rafieemehr  2 , Amin Mirzaeian  4 , Mohieddin Barzegar  1 , Vahid Amiri  1 , Shaghayegh Shahsavan  5 , Mohammad Hossein Mohammadi  1
Affiliations
Review

A concise review on factors influencing the hematopoietic stem cell transplantation main outcomes

Mohammad Rafiee et al. Health Sci Rep. .

Abstract

Background and aims: As a curative procedure, hematopoietic stemcell transplantation (HSCT) is an approved treatment for many malignant orbenign hematologic and non-hematologic diseases. There are different outcomes of HSCT, as well as several parameters influencing these outcomes.

Methods: We had searched scientific sources like Web ofScience and PubMed with a combination of keywords such as HSCT, engraftment,survival, outcomes, etc. Totally, 80 articles were included.

Results: Here we have reviewed the effective factors onmain outcomes of HSCT including engraftment, survival, graft versus hostdisease, and Mobilization. Also, the prediction of hematological reconstitutionand some novel suggestions leading to better outcomes are reviewed.

Conclusion: The study will be applicable for improvedmanagement of autologous and allogeneic HSCT process to increase the procedureefficiency.

Keywords: engraftment; graft vs host disease; hematopoietic stem cell transplantation; outcomes; relapse; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Factors influencing the hematopoietic stem cell transplantation's main outcomes at a glance
FIGURE 2
FIGURE 2
Two important types of HLA in the HSCT are located on the short arm of chromosome 6
See this image and copyright information in PMC

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