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. 2021 Aug;11(4):453-457.
doi: 10.1007/s13659-021-00309-w. Epub 2021 May 11.

New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

Qing-Yun Lu #  1   2 , Jia-Hui Zhang #  1   3 , Ying-Yao Li  1   4 , Xue-Xue Pu  1   5 , Cui-Shan Zhang  1   2 , Shuai Liu  1   2 , Jia-Jia Wan  1   2 , Ying-Tong Di  6 , Xiao-Jiang Hao  7
Affiliations

New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

Qing-Yun Lu et al. Nat Prod Bioprospect. 2021 Aug.

Abstract

One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC50 of 31.9 μM.

Keywords: Cytotoxic activity; Daphnioldhanol A; Daphniphyllum angustifolium hutch; Secodaphnane-type.

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Conflict of interest statement

Authors declare that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
The structures of compounds 1–4
Fig. 2
Fig. 2
1H-1H COSY, key HMBC and ROESY correlations of 1
Scheme 1
Scheme 1
Plausible Biosynthetic Pathway of 1
See this image and copyright information in PMC

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