Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct;48(10):1262-1265.
doi: 10.1111/cup.14060. Epub 2021 Jun 4.

Clinical and histopathological evaluation of cutaneous angiofibromas

Maryam Nasimi  1 , Kambiz Kamyab  2 , Arezou Moradi  1 , Shayan Dasdar  1 , Nika Kianfar  1
Affiliations

Clinical and histopathological evaluation of cutaneous angiofibromas

Maryam Nasimi et al. J Cutan Pathol. 2021 Oct.

Abstract

Background: Angiofibromas are common benign skin lesions that are diagnosed clinically and histopathologically. Fibrous papule (FP) is one of the clinical types of angiofibromas located primarily on the nose.

Methods: The cases with the confirmed diagnosis of angiofibroma were enrolled. Demographic features of the patients and clinical characteristics of the lesions were extracted. Moreover, histopathological features of the available slides were microscopically reviewed.

Results: From 83 cases of cutaneous angiofibromas, 57 (69%) had lesions consistent with FP. The mean age at diagnosis was 37.7 ± 16.3 years and the most common site of involvement was the nose (53% of cases). Regarding the histopathological evaluation of 71 slides, most cases represented vascular changes (97%) and dermal fibroplasia (87%). Melanin incontinence (41%), acanthosis (31%), and lichenoid features (25%) were other common histopathological findings. Moreover, a sparse inflammatory cell infiltrate was present in 68% of cases. The most prevalent inflammatory cells were lymphocytes (61%) and histiocytes (34%).

Conclusion: This study presented the histopathological findings of a series of cutaneous angiofibromas. Dermatopathologists should be aware of these features, especially those that are less common, to better diagnose and differentiate them from malignant neoplasms.

Keywords: angiofibromas; fibrous papule; histopathology; pathology.

PubMed Disclaimer

References

REFERENCES

    1. Meigel WN, Ackerman AB. Fibrous papule of the face. Am J Dermatopathol. 1979;1(4):329-340.
    1. McGibbon DH, Jones EW. Fibrous papule of the face (nose). Fibrosing nevocytic nevus. Am J Dermatopathol. 1979;1(4):345-348.
    1. Graham JH, Sanders JB, Johnson WC, Helwig EB. Fibrous papule of the nose: a clinicopathological study. J Invest Dermatol. 1965;45(3):194-203.
    1. Elifritz J, Krishnan RS, Donnelly H. Numerous fibrous papules of the face unassociated with any genodermatosis. Dermatol Online J. 2007;13(4):12.
    1. Hall MR, Kovach BT, Miller JL. Unilateral facial angiofibromas without other evidence of tuberous sclerosis: case report and review of the literature. Cutis. 2007;80(4):284-288.

LinkOut - more resources