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Meta-Analysis
. 2021 May 13;19(1):105.
doi: 10.1186/s12916-021-01978-7.

Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies

Katherine Davis  1 , Pablo Perez-Guzman  2 , Annika Hoyer  3 , Ralph Brinks  4 , Edward Gregg  5 , Keri N Althoff  6 , Amy C Justice  7 , Peter Reiss  8   9 , Simon Gregson  2   10 , Mikaela Smit  2
Affiliations
Meta-Analysis

Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies

Katherine Davis et al. BMC Med. .

Erratum in

Abstract

Background: Improved access to effective antiretroviral therapy has meant that people living with HIV (PLHIV) are surviving to older ages. However, PLHIV may be ageing differently to HIV-negative individuals, with dissimilar burdens of non-communicable diseases, such as hypertension. While some observational studies have reported a higher risk of prevalent hypertension among PLHIV compared to HIV-negative individuals, others have found a reduced burden. To clarify the relationship between HIV and hypertension, we identified observational studies and pooled their results to assess whether there is a difference in hypertension risk by HIV status.

Methods: We performed a global systematic review and meta-analysis of published cross-sectional studies that examined hypertension risk by HIV status among adults aged > 15 (PROSPERO: CRD42019151359). We searched MEDLINE, EMBASE, Global Health and Cochrane CENTRAL to August 23, 2020, and checked reference lists of included articles. Our main outcome was the risk ratio for prevalent hypertension in PLHIV compared to HIV-negative individuals. Summary estimates were pooled with a random effects model and meta-regression explored whether any difference was associated with study-level factors.

Results: Of 21,527 identified studies, 59 were eligible (11,101,581 participants). Crude global hypertension risk was lower among PLHIV than HIV-negative individuals (risk ratio 0.90, 95% CI 0.85-0.96), although heterogeneity between studies was high (I2 = 97%, p < 0.0001). The relationship varied by continent, with risk higher among PLHIV in North America (1.12, 1.02-1.23) and lower among PLHIV in Africa (0.75, 0.68-0.83) and Asia (0.77, 0.63-0.95). Meta-regression revealed strong evidence of a difference in risk ratios when comparing North American and European studies to African ones (North America 1.45, 1.21-1.74; Europe 1.20, 1.03-1.40).

Conclusions: Our findings suggest that the relationship between HIV status and prevalent hypertension differs by region. The results highlight the need to tailor hypertension prevention and care to local contexts and underscore the importance of rapidly optimising integration of services for HIV and hypertension in the worst affected regions. The role of different risk factors for hypertension in driving context-specific trends remains unclear, so development of further cohorts of PLHIV and HIV-negative controls focused on this would also be valuable.

Keywords: Blood pressure; HIV; Hypertension; Meta-analysis; Systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram of the study selection process. The asterick indicates that this is the number of records selected, based on title and abstract
Fig. 2
Fig. 2
Global distribution of sites used in included studies
Fig. 3
Fig. 3
Forest plot of the risk ratio for hypertension by HIV status, categorised by continent. Values less than one indicate a lower hypertension prevalence in people living with HIV. Estimates were pooled using a random effects model, with a p-value for sub-group differences less than 0.0001. RR risk ratio, CI confidence interval
See this image and copyright information in PMC

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