New CAR's bells and whistles

Comment

M Teresa Villanueva. Nat Rev Drug Discov. 2021 Jun.

. 2021 Jun;20(6):425.

doi: 10.1038/d41573-021-00084-w.

No abstract available

Keywords: Biotechnology; Cancer; Drug discovery; Immunology; Synthetic biology; Therapeutics.

Comment on

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. Choe JH, et al. Sci Transl Med. 2021 Apr 28;13(591):eabe7378. doi: 10.1126/scitranslmed.abe7378. Sci Transl Med. 2021. PMID: 33910979 Free PMC article.
SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models.
Hyrenius-Wittsten A, Su Y, Park M, Garcia JM, Alavi J, Perry N, Montgomery G, Liu B, Roybal KT. Hyrenius-Wittsten A, et al. Sci Transl Med. 2021 Apr 28;13(591):eabd8836. doi: 10.1126/scitranslmed.abd8836. Sci Transl Med. 2021. PMID: 33910981 Free PMC article.

1. Choe, J. H. et al. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Sci. Transl Med. 13, eabe7378 (2021) - PubMed - DOI
1. Hyrenius-Wittsten, A. et al. SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Sci. Transl Med. 13, eabd883 (2021) - DOI