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. 2021 Apr 13;8(5):87-90.
doi: 10.15698/mic2021.05.747.

Means of intracellular communication: touching, kissing, fusing

Anne Spang  1
Affiliations

Means of intracellular communication: touching, kissing, fusing

Anne Spang. Microb Cell. .

Abstract

Eukaryotic cells are complicated factories that need ensure productivity and functionality on the cellular level as well as being able to communicate with their environment. In order to do so cells developed intracellular communication systems. For a long time, research focused mainly on the secretory/biosynthetic and endocytic routes for communication, leaving the communication with other organelles apart. In the last decade, this view has changed dramatically and a more holistic view of intracellular communication is emerging. We are still at the tip of the iceberg, but a common theme of touching, kissing, fusing is emerging as general principles of communication.

Keywords: intracellular traffic; kiss-and-run; membrane contact sites; membrane fusion; signalling.

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Conflict of interest statement

Conflict of Interest: I declare no conflict of interest.

References

    1. Elbaz-Alon Y, Rosenfeld-Gur E, Shinder V, Futerman AH, Geiger T, Schuldiner M. A dynamic interface between vacuoles and mitochondria in yeast. Dev Cell. 2014;30(1):95–102. doi: 10.1016/j.devcel.2014.06.007. - DOI - PubMed
    1. Hönscher C, Mari M, Auffarth K, Bohnert M, Griffith J, Geerts W, van der Laan M, Cabrera M, Reggiori F, Ungermann C. Cellular metabolism regulates contact sites between vacuoles and mitochondria. Dev Cell. 2014;30(1):86–94. doi: 10.1016/j.devcel.2014.06.006. - DOI - PubMed
    1. Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science. 2009;325(5939):477–481. doi: 10.1126/science.1175088. - DOI - PMC - PubMed
    1. Saheki Y, Bian X, Schauder CM, Sawaki Y, Surma MA, Klose C, Pincet F, Reinisch KM, De Camilli P. Control of plasma membrane lipid homeostasis by the extended synaptotagmins. Nat Cell Biol. 2016;18(5):504–515. doi: 10.1038/ncb3339. - DOI - PMC - PubMed
    1. Zhao K, Ridgway ND. Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System. Cell Rep. 2017;19(9):1807–1818. doi: 10.1016/j.celrep.2017.05.028. - DOI - PubMed

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