HLA major allele group frequencies in a diverse population of the Free State Province, South Africa

doi:10.1016/j.heliyon.2021.e06850

. 2021 Apr 21;7(4):e06850.

doi: 10.1016/j.heliyon.2021.e06850. eCollection 2021 Apr.

HLA major allele group frequencies in a diverse population of the Free State Province, South Africa

Walter J Janse van Rensburg¹, André de Kock^{2

3}, Chené Bester¹, Jean F Kloppers^{2

3}

Affiliations

¹ Human Molecular Biology Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
² Department of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
³ National Health Laboratory Service, Universitas Academic Business Unit, Bloemfontein, South Africa.

PMID: 33981900
PMCID: PMC8085688
DOI: 10.1016/j.heliyon.2021.e06850

HLA major allele group frequencies in a diverse population of the Free State Province, South Africa

Walter J Janse van Rensburg et al. Heliyon. 2021.

. 2021 Apr 21;7(4):e06850.

doi: 10.1016/j.heliyon.2021.e06850. eCollection 2021 Apr.

Authors

Walter J Janse van Rensburg¹, André de Kock^{2

3}, Chené Bester¹, Jean F Kloppers^{2

3}

Affiliations

¹ Human Molecular Biology Unit, School of Biomedical Sciences, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
² Department of Haematology and Cell Biology, School of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
³ National Health Laboratory Service, Universitas Academic Business Unit, Bloemfontein, South Africa.

PMID: 33981900
PMCID: PMC8085688
DOI: 10.1016/j.heliyon.2021.e06850

Abstract

Background: Human Leucocyte Antigens (HLA) play a vital role in disease pathogenesis and transplant rejection. HLA-typing is a useful tool in predicting disease progression and to identify potential organ donors. Due to human migration and known ethnic variation, frequent targeted HLA sequencing of specific populations is crucial to increase their representation in global reference panels.

Materials and methods: We performed a retrospective file audit of all HLA-typings done in our setting from 2005-2019. We discuss data for the major HLA-A, HLA-B, HLA-C, and HLA-DRB1 allele groups.

Results: Overall, the most common allele groups were HLA-A∗02, HLA-B∗15, HLA-C∗07 and HLA-DRB1∗03. For the African descent group, the most common alleles were HLA-A∗30, HLA-B∗15, HLA-C∗07 and HLA-DRB1∗03. For the European descent group, the most common alleles were HLA-A∗02, HLA-B∗07, HLA-C∗07 and HLA-DRB1∗15. For the mixed ancestry group, the most common allele groups were HLA-A∗02, HLA-B∗15, HLA-C∗02 and HLA-DRB1∗13. HLA-B∗44 was identified as the most common allele group in patients with renal failure.

Discussion and conclusion: The significant variation within the HLA frequencies between the different ethnic groups highlights the value of population-specific HLA-typing. Furthermore, the identification of HLA-B∗44 as a prominent HLA in our renal failure population warrants in-depth investigation of this group.

Keywords: Allele frequency; Human leucocyte antigen; South Africa; Transplantation.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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[1] Terasaki P.I. UCLA Tissue Typing Laboratory; Los Angeles: 1990. History of HLA: Ten Recollections.

[2] Terasaki P.I. UCLA Tissue Typing Laboratory; Los Angeles: 1990. History of HLA: Ten Recollections.

[3] Beck S., Trowsdale J. The human major histocompatibility complex: lessons from the DNA sequence. Annu. Rev. Genom. Hum. Genet. 2000;1(1):117–137. - PubMed

[4] Beck S., Trowsdale J. The human major histocompatibility complex: lessons from the DNA sequence. Annu. Rev. Genom. Hum. Genet. 2000;1(1):117–137. - PubMed

[5] Marsh S.G.E., Albert E.D., Bodmer W.F. Nomenclature for factors of the HLA system, 2004. Tissue Antigens. 2005;65(4):301–369. - PubMed

[6] Marsh S.G.E., Albert E.D., Bodmer W.F. Nomenclature for factors of the HLA system, 2004. Tissue Antigens. 2005;65(4):301–369. - PubMed

[7] Wong L.P., Ong R.T.H., Poh W.T. Deep whole genome sequencing of 100 southeast Asian Malays. Am. J. Hum. Genet. 2013;92(1):52–66. - PMC - PubMed

[8] Wong L.P., Ong R.T.H., Poh W.T. Deep whole genome sequencing of 100 southeast Asian Malays. Am. J. Hum. Genet. 2013;92(1):52–66. - PMC - PubMed

[9] Horton R., Wilming L., Rand V. Gene map of the extended human MHC. Nat. Rev. Genet. 2004;5:889–899. - PubMed

[10] Horton R., Wilming L., Rand V. Gene map of the extended human MHC. Nat. Rev. Genet. 2004;5:889–899. - PubMed

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HLA major allele group frequencies in a diverse population of the Free State Province, South Africa

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HLA major allele group frequencies in a diverse population of the Free State Province, South Africa

Authors

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