Anterior lenticular opacities in Costello Syndrome

Abstract

Purpose: A case of anterior lenticular opacities in a patient of Costello Syndrome is reported.

Observations: Bilateral anterior capsular plaque along with anterior lens opacities (Anterior Segment Optical Coherence Tomography) has been demonstrated in a patient of Costello Syndrome presenting with atopic dermatitis.

Conclusions: All patients with Costello Syndrome require a detailed anterior segment examination and a close follow up, as even minute lenticular opacities cause visual impairment leading to amblyopia and may require an early surgical intervention.

Keywords: Anterior capsular plaques; Costello; Lenticular.

Fig. 1

A. Clinical picture of the patient showing coarse facial features along with low set ears, hair on the forehead, hemangioma over the right eyebrow, depressed nasal bridge and unusually thick lips. B Clinical picture of abnormally thickened skin over the dorsum of both the hands. C Clinical image of the planter aspect of the hands showing deep palmoplantar creases. D Picture (magnified view) of the palmer aspect of the fingers showing pachydermatoglyphia. E Picture of the nape of the neck showing cutaneous papillomas along with acanthosis nigrans.

Fig. 2

A. Slit lamp diffuse examination of the right eye showing linear capsular plaque along with a small lenticular opacity. B Slit lamp diffuse examination of the left eye showing round capsular plaque along with a wool like central lenticular opacity.

Fig. 3

A. Swept-Source OCT of the right eye showing anterior capsular plaque along with opacity in the anterior part of the lens. B. Swept-Source OCT of the left eye showing anterior capsular plaque along with opacity in the anterior part of the lens.